足月新生儿高胆红素性脑损伤不同血清指标的临床意义  

Study on relationship of s-NSE and different serum indexes in neonates with hyperbilirubinemia

作　　者：陈宝昌[1] 戴兰芬[2] 任常军[1] 张晶[1] 

机构地区：[1]河北医科大学第一医院儿科,河北石家庄050031 [2]河北省儿童医院儿内科,河北石家庄050031

出　　处：《中国儿童保健杂志》2014年第7期771-773,共3页Chinese Journal of Child Health Care

基　　金：河北省科技攻关课题(052761629)

摘　　要：目的研究新生儿胆红素性脑损伤患儿血清神经元特异性烯醇化酶(serum neuron-specific enolase,sNSE)含量与血清胆红素、白蛋白及B/A值的关系。方法采用ELISA法测定高胆红素血症新生儿血清s-NSE含量,全自动生化分析仪测定其血清间接胆红素数值(UCB)、白蛋白数值(A),计算间接胆红素与白蛋白的比值(B/A);将62例sNSE含量增高患儿分成两组:s-NSE值轻度增高组和s-NSE值重度增高组,分析两组血清指标的差异,以及s-NSE值与各指标的相关性。结果两组间UCB值差异有统计学意义(P<0.05),A值无统计学意义(P>0.05),B/A值差异有统计学意义(P<0.001);s-NSE值与B/A值呈高度正相关性(r=0.687,P<0.001)。结论 B/A比值能较好的反应胆红素性脑损害,临床可通过对B/A值的监测,指导高胆红素血症患儿的合理干预。Objective To explore relationships of serum neuron-specific enolase （NSE） and serum bilirubin,albumin and B/A values,in neonates suffering from hyperbilirubin-induced brain injury. Methods Serum NSE contents （s-NSE）of hyperbilirubinemia infants were determined by ELISA. Serum indirect bilirubin values （s-UCB） and albumin values （A） were measured by full-automatic biochemical analyzerm,and indirect bilirubin and albumin ratio （B/A） was calculated. The 62 cases with increased s-NSE concentrations were devided into two groups mildly increased s-NSE values group and highly increased s-NSE values group,then differences of serum indicators from the two groups, and correlations of s-NSE values and the serum indicators were analyzed. Results There were significant difference in s-UCB value （P〈0.05） ,no signifi- cant difference in A values （P〉0.05） ,and very significant difference in B/A value （P〈0. 001） between two groups. There was a good positive correlation between s-NSE value and the B/A value （r=0. 687,P〈0. 001）. Conclusions B/A ratio could be a good mark to hyperbilirubin-induced brain injury. Through monitoring B/A ratio, neonates with hyperbilirubi- nemia may reasonably be intervened.

关 键 词：胆红素 血清指标 脑损伤 新生儿 

分 类 号：R722.1[医药卫生—儿科]