IgG4相关桥本甲状腺炎的研究进展  

Recent progress of IgG4-related Hashimoto＇s thyroiditis

作　　者：李秀娟[1] 刘红梅[1] 

机构地区：[1]重庆医科大学附属第一医院第一分院内分泌科,400015

出　　处：《国际内分泌代谢杂志》2014年第4期257-259,共3页International Journal of Endocrinology and Metabolism

摘　　要：研究发现部分桥本甲状腺炎患者的甲状腺组织中有大量IgG4阳性浆细胞浸润,提示其可能是一种IgG4相关性疾病.根据免疫组化染色结果可以将桥本甲状腺炎分为IgG4相关型和非IgG4相关型;IgG4相关型桥本甲状腺炎患者甲状腺组织表现出明显的间质纤维化、淋巴细胞浸润以及滤泡细胞破坏;区分桥本甲状腺炎不同亚型,有利于早期发现和治疗重症桥本甲状腺炎患者.Studies show that there are large numbers of IgG4-positive plasma cells in the thyroid of Hashimoto＇s thyroiditis （HT） patients,which suggesting that this type of HT might have a close relationship with IgG4-related disease.Based on the immunostaining results for IgG4,patients with HT can be divided into IgG4-related type and non-IgG4 related.Histopathological examination of thyroid in patients with IgG4-related HT shows a higher grade of stromal fibrosis,lymphoplasmacytic infiltration and follicular cell degeneration.Classification of HT subtypes is beneficial to early detection and treatment of severe HT patients.

关 键 词：IGG4 桥本甲状腺炎 纤维化 

分 类 号：R581.4[医药卫生—内分泌]