慢波睡眠与2型糖尿病  

Relationship between slow wave sleep and type 2 diabetes

作　　者：李昂[1] 张俊清[1] 张成[2] 马靖[2] 

机构地区：[1]北京大学第一医院内分泌科,100034 [2]北京大学第一医院呼吸和危重症科,100034

出　　处：《国际内分泌代谢杂志》2014年第4期267-270,共4页International Journal of Endocrinology and Metabolism

摘　　要：慢波睡眠减少是睡眠障碍的一个重要表现.慢波睡眠的启动伴随多种神经内分泌及代谢变化,这些变化大多与糖代谢相关.影响慢波睡眠的许多病理、生理因素亦与2型糖尿病（T2DM）发病风险增加相关.睡眠干预研究发现,慢波睡眠减少可导致糖耐量正常者胰岛素敏感性降低,交感兴奋性增加是主要原因;T2DM患者睡眠结构的一个重要变化是慢波睡眠减少,且该变化独立于呼吸睡眠障碍存在.鉴于慢波睡眠对血糖稳态的影响以及T2DM患者睡眠结构的改变,提示慢波睡眠与T2DM之间可能存在一定联系.Reduced slow wave sleep （SWS） is a common manifestation of sleep disorders.Accompanied with SWS,there are a variety of neuroendocrine and metabolic changes,most of which are linked to glucose metabolism.Many physiologic and pathologic factors affecting SWS are associated with increased risk of type 2 diabetes （T2DM）.Studies on sleep have found that insulin sensitivity is impaired in subjects with normal glucose tolerance after short term suppression of SWS.Increased sympathetic activity may contribute to this effect.Patients with T2DM have less time of SWS than normal subjects.This change is independent of the influence of sleep-disordered breathing.Given the impacts of SWS on glucose homeostasis,as well as changes in sleep architecture of patients with diabetes,a possible interaction may exists between SWS and diabetes.

关 键 词：慢波睡眠 血糖稳态 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]