胰高血糖素样肽-1与骨骼肌葡萄糖代谢  

Glucagon-like peptide-1 and glucose metabolism in the skeletal muscle

作　　者：黄婷婷[1] 沈飞霞[1] 谷雪梅[1] 

机构地区：[1]温州医科大学附属第一医院内分泌科,325000

出　　处：《国际内分泌代谢杂志》2014年第4期281-282,共2页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81000356）

摘　　要：胰高血糖素样肽-1（GLP-1）具有葡萄糖依赖的促胰岛素分泌及降糖作用.其促进胰岛素释放,抑制胰高血糖素产生,从而调节血糖.骨骼肌作为重要的维持糖代谢平衡的胰岛素靶器官,存在丰富的GLP-1受体.GLP-1通过作用于受体可增强葡萄糖转运及促进糖原合成.Glucagon-like peptide-1 （GLP-1） plays an important role in glucose-dependent insulinotropic and antidiabetic properties.GLP-1 stimulates insulin secretion and inhibits glucagon release,thereby regulating blood glucose.As an important insulin target organ,skeletal muscle with abundant GLP-1 receptors maintains a balance of glucose metabolism.GLP-1 enhances glucose transport and glycogen synthesis by binding GLP-1 receptor on skeletal muscular cells.

关 键 词：胰高血糖素样肽-1 骨骼肌 葡萄糖代谢 

分 类 号：R587.1[医药卫生—内分泌]