山楂叶总黄酮磷脂复合物的表征与体外释药特性研究  

Study on Characterization and in Vitro Release of Hawthorn Leaves Flavonids Phospholipid Complex

作　　者：高敏[1,2] 石森林[1] 王鑫波 童丽姣 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]上海睿智化学研究有限公司,上海201203 [3]临安市中医院,临安311300

出　　处：《中华中医药学刊》2014年第7期1704-1707,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技项目(2008CA090)

摘　　要：目的:对山楂叶总黄酮磷脂复合物进行表征,并考察其体外释药特性。方法:采用紫外光谱、红外光谱,X-射线衍射分析法与溶解度法,表征山楂叶总黄酮磷脂复合物;动态透析法评价山楂叶总黄酮磷脂复合物的体外释放特性。结果:与原辅料及其物理混合物比较,山楂叶总黄酮磷脂复合物的红外光谱,X-射线衍射图均有一定改变;山楂叶总黄酮磷脂复合物在磷酸盐缓冲液(pH 7.4)溶液中的释放遵循Higuchi方程。结论:山楂叶总黄酮磷脂复合物的体外释放以被动扩散为主。Objective：The characterization and in vitro release study of Hawthorn Leaves Flavonids Phospholipid Complex（HLF-PPC） were studied.Method：The characterization of HLF-PPC was analyzed by using the ultraviolet spectrum,infrared spectrum,and differential scanning.Dynamic dialysis method was used to determine the release characteristic of HLF-PPC in vitro.Result：Compared with the raw materials and the physical mixture,there was certain difference absorption spectra of HLF-PPC.The drug release behavior of HLF-PPC in phosphate buffered（pH 7.4） was described by Higuchi mode.Conclusion：HLF-PPC was passive diffusion in vitro.

关 键 词：山楂叶总黄酮 磷脂复合物 体外释放 

分 类 号：R284[医药卫生—中药学]