马来酸依那普利分散片的制备  

Preparation of Enalapril Maleate Dispersible Tablets

作　　者：沈澍[1] 

机构地区：[1]溧阳人民医院,江苏常州213300

出　　处：《中国医药指南》2014年第19期72-73,共2页Guide of China Medicine

摘　　要：目的制备马来酸依那普利分散片。方法以崩解时限为指标,采用单因素考察和正交设计实验,对马来酸依那普利分散片处方及制剂工艺进行筛选、优化。结果选择MCC∶乳糖=1∶2为填充剂,5%PVP K17乙醇溶液为黏合剂,7%立崩为崩解剂。按优选处方和工艺制备的马来酸依那普利分散片符合《中华人民共和国药典》中有关分散片的要求。结论与普通片相比,马来酸依那普利分散片崩解迅速,制备工艺简单,操作方便。Objective To prepare enalapril maleate dispersible tablets. Methods By using single-factor and orthogonal test, the prescription of enalapril maleate dispersible tablets and the preparation process were optimized using disintegration time as index. Results MCC∶lactose=1∶2, 5%PVP K17 alcohol solution and 7%Libeng were chose as filler, adhesives, and disintegrants respectively;Enalapril maleate dispersible tablets prepared using optimized prescription and technology meted the requirements of Chinese Pharmacopeia 2010. Conclusion Compared with conventional tablets, enalapril maleate dispersible tablets showed noticeable advantages of rapid disintegration and easy to prepare.

关 键 词：马来酸依那普利 分散片 崩解 

分 类 号：R972.4[医药卫生—药品]