慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能和内环境稳态的影响  

Effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice

作　　者：陈刘芳[1] 付泉源[1] 万晶[1] 张宗泽[1] 王焱林[1] 吴云[1] 

机构地区：[1]武汉大学中南医院麻醉科,430071

出　　处：《中华麻醉学杂志》2014年第4期451-453,共3页Chinese Journal of Anesthesiology

基　　金：国家自然科学基金（81201499）

摘　　要：目的 评价慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能和内环境稳态的影响.方法 清洁级健康昆明种雄性小鼠36只,40 d龄,体重25～30 g,采用随机数字表法,将其分为3组（n=12）：正常对照组（C组）、0.1％七氟醚组（L组）和0.5％七氟醚组（H组）.每天18：00至6：00吸入七氟醚,持续30 d,L组和H组浓度分别为0.1％和0.5％,吸入27-30 d期间进行水迷宫实验.然后经左心室采集血样,进行血气分析和电解质指标检测.结果 3组小鼠水迷宫实验中游出时间、错误次数及血气分析、电解质指标差异无统计学意义（P＞0.05）.结论 慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能及内环境稳态无明显影响.Objective To evaluate the effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice.Methods Thirty-six healthy male Kunming mice,aged 40 days,weighing 25-30 g,were randomly assigned into 3 groups （n =12 each）：control group （group C）,0.1% sevoflurane group （group L） and 0.5 % sevoflurane group （group H）.The mice inhaled 0.1% （group L） or 0.5% sevoflurane （group H） between 18：00-6：00 （the next day） every night for 30 days.Water maze test was performed at 27-30 days of inhalation.Blood samples were collected from the left ventricle for blood gas analysis and for determination of blood electrolytes.Results There was no significant difference in swimming time in Water maze test,number of errors and blood gas analysis and blood electrolytes.Conclusion Chronic exposure to subanesthetic concentrations of sevoflurane has no significant effects on memory function and homeostasis of mice.

关 键 词：麻醉药 吸入 职业暴露 记忆 内环境稳定 

分 类 号：R614[医药卫生—麻醉学]