白蛋白尿与甲状腺激素的相关性分析  

Association of thyroid dysfunction and albuminuria：a cross-sectional study

作　　者：黄文娟[1] 杜新[1] 潘斌斌[1] 尹忠诚[1] 曹长春[1] 

机构地区：[1]徐州医学院,江苏221002

出　　处：《国际泌尿系统杂志》2014年第4期545-548,共4页International Journal of Urology and Nephrology

基　　金：国家自然科学基金面上项目（81170658）和南京医科大学科技发展基金（2011NJMU195,2012NJMU233）资助

摘　　要：目的 对临床慢性肾脏病（CKD）患者白蛋白尿与甲状腺激素水平进行相关性分析,为临床医生诊断、治疗提供客观依据.方法 收集CKD患者血清样本和24h尿液,分别测定甲状腺激素水平（T3、T4、FT3、FT4、TSH）和24h尿白蛋白,根据KDIGO指南对尿白蛋白进行分组（30mg/24h、30～ 300mg/24h、＞300mg/24h）.结果 T4、FT4在尿白蛋白不同分期存在显著差异性（P＜0.005）,T4、FT4、T3、FT3与24h尿白蛋白有相关性（Pearson相关系数分别为0.243、0.230、0.209、0.138;P ＜0.005）.结论 T4、FT4与白蛋白尿呈正相关.Objectives To investigate the relationship between serum thyroid hormone in patients with chronic renal failure and albuminuria,which can provide an objective basis for the clinicians in the diagnosis and treatment of chronic kidney disease.Methods The serum samples of patients with chronic kidney disease group were collected and tested in Nanjing first hospital and then statistical analyzed.The clinical characteristics consisted of 5 items of thyroid hormone （thyrotropin,total T3,free T3,total T4 and free T4） were recorded.Different albuminuria groups were set through the level of albuminuria according to the KDIGO guideline.Results Total T4 and free T4 were significantly different in ACR ＜30mg/g,30-300mg/g and ＞300mg/g （both P =0.000）.Positive relationship between T4、FT4 、T3、FT3 and albuminuria were found through correlation analysis （Pearson correlation coefficient were 0.243,0.230,0.209 and 0.138 respectively,with P =0.000）.Conclusions T4、FT4 were positively correlated with albuminuria.

关 键 词：肾疾病 白蛋白尿 甲状腺激素类 

分 类 号：R692[医药卫生—泌尿科学]