一氧化氮在结核分支杆菌感染巨噬细胞中的作用研究进展  

Progress on Effects of Nitric Oxide in Process of Mycobacterium tuberculosis Infection in Macrophages

作　　者：何玉龙 张文清[1,2] 吴月红[1,2] 

机构地区：[1]宁夏大学西部特色生物资源保护与利用教育部重点实验室,宁夏银川750021 [2]宁夏大学生命科学学院,宁夏银川750021

出　　处：《动物医学进展》2014年第7期90-93,共4页Progress In Veterinary Medicine

基　　金：国家重点基础研究发展计划(973)项目(2012CB126301;2012CB518801);宁夏自治区自然科学基金项目(NZ12105);宁夏回族自治区留学人员创新创业个人项目择优资助项目(2012-03)

摘　　要：结核病是由结核分支杆菌感染引起的严重危害人类健康的慢性传染病,也是全球关注和亟待解决的重要公共卫生和社会问题。结核分支杆菌与宿主巨噬细胞的相互作用及机制对结核病的病理发生和发展起着重要的作用。巨噬细胞通过诱导型一氧化氮合酶(iNOS)产生的一氧化氮(NO)在抵御及杀灭包括结核分支杆菌在内的病原微生物中起重要的作用。论文就结核分支杆菌感染人类及小鼠巨噬细胞后NO的产生及其作用进行综述,为进一步了解人类结核病致病及防御机制提供参考。Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection which is harmful to human health,therefore,it is an important public health and global-concerned social problem to be solved.The mechanisms of interaction between Mycobacterium tuberculosis and host macrophages play key roles in the process of its pathogenesis and development.Nitric oxide（NO）produced by inducible nitric oxide synthase（iNOS）in macrophages plays an important role in resisting and kill pathogenic microorganisms.In this paper,the production and effects of NO produced by human and murine macrophages after the infection with Mycobacterium tuberculosis were reviewed,so as to provide the basis for further understanding and investigation of the human tuberculosis pathogenesis and defense mechanisms.

关 键 词：结核分支杆菌 一氧化氮 巨噬细胞 一氧化氮合成酶 

分 类 号：S852.618[农业科学—基础兽医学]