感染后咳嗽气道神经源性炎症水平与肺功能相关性研究  

Association Study of Airway Neurogenic Inflammation Level in Sputum Supernatant and Pulmonary Function in Cough Post Infectious

作　　者：何雪梅 卢育明[2] 

机构地区：[1]广东省深圳市深圳沙河医院,广东深圳518053 [2]广东省中山市中医院

出　　处：《中国医学创新》2014年第19期4-6,共3页Medical Innovation of China

基　　金：中山市科技计划项目(20132A177)

摘　　要：目的:探讨气道感觉神经末梢(主要是C纤维末梢)释放的P物质(SP)在感染后咳嗽(CPI)发病机制中的作用与地位,并阐述其与肺功能之间的关系。方法:选取2012年5月-2013年12月深圳市沙河医院内科门诊及住院患者37例作为病例组,另外选取35例健康成人志愿者作为正常对照组,观察两组0、28 d痰上清液中SP水平,测试相应时间点肺功能的情况。结果:病例组内28 d痰上清液中SP较0 d明显升高(P<0.05),且组内28 d对应时间点的FEV1及FEV1/FVC较0 d均明显下降(P<0.05)。病例组0、28 d痰上清液中SP较正常对照组均明显升高(P<0.01),同样,病例组28 d对应时间点的FEV1及FEV1/FVC较正常对照组的28 d均明显下降(P<0.01)。由此可见,肺功能中FEV1及FEV1/FVC指标与SP呈反相关(P<0.05)。结论:气道敏感性增高并伴随以痰上清液中SP增高为特点的气道神经源性炎症是CPI的重要特征,可能在CPI咳嗽发病机制中起到重要作用。Objective：To investigate the effect of the level of SP（released from airway sensory nerve endings, mainly C nerve fiber） in CPI pathogenesis and elaborate its relation with pulmonary function.Method：37 CPI patients outpatient and inpatient in Shenzhen Shahe hospital were selected as the case group,and 35 healthy adult volunteers were selected as the normal control group,observed their SP levels of in sputum supernatant on 0 d and 28 d and tested the pulmonary function at the same time.Result：In the cases group,the SP level of in sputum supernatant at 28 d was significantly higher than that at 0 d（P〈0.05）,the corresponding time point of FEV1,FEV1/FVC at 28 d were significantly lower than those at 0 d（P〈0.05）.The SP levels of in sputum supernatant at 0,28 d were significantly higher than those in the normal control group（P〈0.01）,also the corresponding time point of FEV1,FEV1/FVC at 28 d in the case group were were significantly lower than those in the normal control group at 0 d（P〈0.01）.Thus FEV1 and FEV1/FVC indexes in Pulmonary Function Test were negatively related to SP in sputum supernatant.Conclusion：Airway neurogenic inflammation signified with increasing airway sensitivity and SP level is an important character of CPI and may play a key role in its pathogenesis.

关 键 词：感染后咳嗽 神经源性炎症 肺功能 

分 类 号：R56[医药卫生—呼吸系统]