2型糖尿病患者血清胰岛素原与载脂蛋白A1、载脂蛋白B关系研究  

Study on the Relationship between Proinsulion and Apo-A1, Apo-B in the Patients with Type 2 Diabetes

作　　者：张俊防[1] 姚海延 彭若宇[1] 

机构地区：[1]南方医科大学第三附属医院内科,中国广州510630

出　　处：《国际老年医学杂志》2014年第4期148-151,共4页International Journal of Geriatrics

摘　　要：目的：研究2型糖尿病患者中血清胰岛素原（PI）与载脂蛋白A1（Apo-A1）、载脂蛋白B （Apo-B）的关系。方法：将所有受试者83例，以空腹血清PI水平中位数为界值，分为两组，高PI组和对照组，均行空腹口服葡萄糖耐量试验，空腹采血测PI、真胰岛素（ TI）、 Apo-A1、 Apo-B、总胆固醇（ TC）、三酰甘油（ TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血糖、糖化血红蛋白，糖负荷后2h采血检测TI、 PI、血糖，计算胰岛素抵抗指数，并测量身高、体重、腰围、臀围、血压等指标进行比较分析。结果：在高PI组， Apo-A1、 HDL-C显著降低， Apo-B、 TC、 TG、 LDL-C显著升高， TI、 HOMA-IR也显著升高；直线相关分析显示，空腹血清PI 水平与Apo -A1、Apo-B以及TC、 TG、 LDL-C、 HDL-C均显著相关；2h PI水平与Apo-A1、 Apo-B、 TG、 LDL-C、 HDL-C也显著相关，与TC不相关；进一步多重线性回归分析显示，校正性别、年龄、体质量指数等参数后， PI与Apo-A1、 Apo-B仍显著相关，2h PI、2h TI只与Apo-B相关，与Apo-A1不再相关。结论：2型糖尿病高PI组患者，存在更明显的Apo-A1下降和Apo-B升高，及其它脂质代谢异常，胰岛素原与Apo-A1下降和Apo-B升高密切相关。OBJECTIVE： To evaluate the relationship between proinsulion and Apo -A1, Apo-B in the patients with type 2 di-abetes.METHODS： All the 83 cases were divided into two groups according to their serum proinsulion （ PI） median： higher PI group and control group.OGTT tests were conducted with the subjects.Fasting and 2hPI, true insulin （TI）, plasma glucose, Apo-A1, Apo-B, TC, TG, LDL-C, HDL-C, glycosylated hemoglobin （HbA1c） and blood pressure were all measured .Homeo-stasis model assessment insulin resistance index （ HOMA-IR） was calculated .RESULTS： In higher PI group Apo-A1 and HDL-C were lower; Apo-B, TC, TG and LDL-C were higher; TI and HOMA-IR were higher than those in control group; Pearson correlation analysis showed that fasting serum PI was significantly correlated with Apo -A1, Apo-B, TC, TG, LDL-C and HDL-C.2hPI was also significantly correlated with Apo -A1, Apo-B, TG, LDL-C and HDL-C, but not correlated with TC .After adjusting gender , age and BMI , further multivariable linear regression analysis indicated that PI and TI were still significantly correla -ted with Apo-A1 and Apo-B.2h PI and 2h TI were correlated with Apo -B only, not correlated with Apo -A1.CONCLUSION：In higher PI group with type 2 diabetes Apo -A1 is lower and Apo-B is higher, and other abnormal lipid metabolism also exists . True insulion and proinsulion are closely related to this metabolic disorder .

关 键 词：2型糖尿病 胰岛素原 载脂蛋白A1 载脂蛋白B 

分 类 号：R587.1[医药卫生—内分泌]