2010～2012年某院临床常见病原菌耐药性分析  

Analysis of clinical antibiotic resistance of common pathogenic bacteria in a hospital from2010to 2012

作　　者：卢雁英[1] 粟永俊[1] 王章涛[1] 

机构地区：[1]广西壮族自治区南宁市第一人民医院检验科,530022

出　　处：《检验医学与临床》2014年第13期1785-1787,共3页Laboratory Medicine and Clinic

摘　　要：目的了解南宁市第一人民医院2010年1月至2012年12月临床常见病原菌对常用抗菌药物的耐药情况,为临床抗菌药物的合理使用提供依据。方法对2010年1月至2012年12月临床标本分离出的病原菌药敏试验结果进行回顾性分析。结果 3年共分离出病原菌10 153株,其中革兰阴性杆菌占61.2%,革兰阳性球菌占26.6%,真菌占12.2%。分离数排列前6位的病原菌为:绿脓假单胞菌(16.6%)、大肠埃希菌(14.5%)、肺炎克雷伯菌(11.6%)、白色念珠菌(9.8%)、鲍曼不动杆菌(5.4%)、金黄色葡萄球菌(4.1%)。革兰阴性杆菌对亚胺培南、阿米卡星、派拉西林/他唑巴坦敏感,对氨苄西林、复方磺胺甲噁唑耐药率高;革兰阳性球菌对万古霉素、哌拉西林/他唑巴坦敏感,对红霉素、氨苄西林、青霉素耐药;白色念珠菌对两性霉素B、制霉菌素、5-氟胞嘧啶敏感。结论医院分离的常见病原菌为革兰阴性杆菌,临床应重视病原菌的耐药性监测,在治疗过程中合理使用抗菌药物。Objective To analyze the drug resistance of clinical common pathogenic bacteria in this hospital.Methods Results of drug sensitive test of pathogenic bacteria during Jan.2010and Dec.2012were retrospectively analyzed.Results A total of 10 153strains of bacteria were isolated within the three years,among which Gram negative bacilli accounted for 61.2%,Gram positive bacteria accounted for 26.6%,fungi accounted for 12.2%.The most common six kinds of pathogenic bacteria were Pseudomonas aeruginosa（16.6%）,Escherichia coli（15.0%）,Klebsiella pneumoniae（11.6%）,Candida albicans（9.8%）,Acinetobacter baumannii（5.1%）,and Staphylococcus aureus（4.1%）.Gram negative bacteria were sensitive to imipenem,amikacin,piperacillin/Tazo,and resistant to ampicillin and compound sulfamethoxazole.Gram positive bacteria were sensitive to vancomycin and piperacillin/Tazo,but resistant to erythromycin and ampicillin.Candida albicans were sensitive to amphotericin B,nystatin and 5-flurocytosine.Conclusion The most common pathogenic bacteria isolated in this hospital might be gram negative bacteria.More attention should be paid for the monitoring of drug resistance of pathogenic bacteria.Antibiotics should be rationally used in the treatment.

关 键 词：抗菌药物 病原菌 耐药性 

分 类 号：R197.32[医药卫生—卫生事业管理]