盐酸坦索罗辛联合酒石酸托特罗定治疗慢性前列腺炎/慢性骨盆痛综合征60例  

Effects of tamsulosin hydrochloride combined with tolterodine tartrate for treating 60 patients with chronic prostatitis/chronic pelvic pain syndrome

作　　者：宋小松 甘艺平 余强国 陈勇[2] 孙伟[2] 肖卫忠[2] 

机构地区：[1]佛山市南海第二人民医院泌尿外科,广东佛山528251 [2]重庆市涪陵中心医院泌尿外科,重庆408000

出　　处：《现代医药卫生》2014年第13期1944-1946,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨盐酸坦索罗辛联合酒石酸托特罗定(托特罗定L-酒石酸盐)治疗慢性前列腺炎/慢性骨盆痛综合征(CP/CPPS)的临床效果。方法将2010年9月至2011年9月收治的60例CP/CPPS患者随机分为观察组和对照组各30例。观察组患者给予盐酸坦索罗辛(2 mg、每晚1次)联合酒石酸托特罗定(4 mg、每天1次)治疗,对照组患者给予盐酸坦索罗辛(2 mg、每晚1次)联合安慰剂(1粒、每天1次)治疗,3、6个月后观察慢性前列腺炎症状指数评分(CPSI)、最大尿流率、残余尿量及前列腺液常规检查等变化。结果治疗3、6个月观察组患者CPSI总分下降[分别为(14.5±6.3)、(12.8±5.7)分]、排尿症状评分改善[分别为(3.5±2.1)、(3.1±2.3)分]优于对照组[CPSI总分下降分别为(10.2±7.6)、(9.3±6.7)分,排尿症状评分改善分别为(2.1±1.7)、(1.8±1.4)分],差异均有统计学意义(P<0.05)。两组患者最大尿流率、残余尿量比较,差异均无统计学意义(P>0.05)。结论盐酸坦索罗辛联合酒石酸托特罗定治疗CP/CPPS较单用盐酸坦索罗辛疗效明显,尤其适合排尿症状较重的患者。Objective To explore the clinical efficacy of tamsulosin hydrochloride combined with tolterodine tartrate in the treatment of chronic prostatitis/chronic pelvic pain syndrome（CP/CPPS）. Methods A total of 60 patients with CP/CPPS,who were received from September 2010 to September 2011,were randomized into observation group and control group,30 cases in each group. The observation group was treated with tamsulosin hydrochloride（2 mg,once every night） combined with tolterodine tartrate（4 mg,once daily）,while the control group was administered with tamsulosin hydrochloride（2 mg,once every night） combined with placebo（1 capsule,once daily）,after 3 and 6 months,the changes of chronic prostatitis symptom index（CPSI）,maximum urine flow rate,residual urine and routine inspection of prostatic fluid were observed. Results 3 and 6 months after treatment,the total scores decline of CPSI and urinary symptom score in observation group [（14.5±6.3）,（12.8±5.7）;（3.5±2.1）,（3.1±2.3）] were better than those of the control group [（10.2±7.6）,（9.3±6.7）;（2.1±1.7）,（1.8±1.4）], with statistically significant difference（P〈0.05）. The difference between the two groups on maximum urine flow rate and residual urine had no statistical significance（P〉0.05）. Conclusion The efficacy of tamsulosin hydrochloride combined with tolterodine tartrateis is better than tamsulosin hydrochloride alone in treating CP/CPPS,especially for the patients with more serious urinary symptom.

关 键 词：前列腺炎/药物疗法 骨盆痛/药物疗法 坦索罗辛 托特罗定 

分 类 号：R983[医药卫生—药品]