替米沙坦联合苯磺酸氨氯地平治疗晨峰高血压疗效观察  

Clinical study of morning blood pressure surge treated by telmisartan with amlodipine besylate

作　　者：杨梅 赵棵 

机构地区：[1]重庆市南岸区中西医结合医院内科,重庆400061

出　　处：《现代医药卫生》2014年第13期1951-1952,共2页Journal of Modern Medicine & Health

摘　　要：目的观察替米沙坦联合苯磺酸氨氯地平治疗晨峰高血压的临床疗效。方法将2012年8月至2013年6月收治的100例高血压患者随机分为两组,每组50例。治疗组睡前服用替米沙坦80 mg,清晨服用苯磺酸氨氯地平5 mg;对照组清晨服用替米沙坦80 mg及吲达帕胺缓释片1.5 mg。结果两组治疗后24 h平均血压、白天平均血压、夜间平均血压较治疗前明显下降,差异有统计学意义(P<0.05);两组在治疗后收缩压差值较治疗前明显减小,差异有统计学意义(P<0.05);在治疗后,治疗组的收缩压差值与对照组比较明显减小,差异有统计学意义(P<0.05);血压晨峰(MBPS)现象控制率治疗组为88%,对照组为56%,两组比较,差异有统计学意义(P<0.05);两组患者的不良反应发生率低,症状轻微。结论替米沙坦联合苯磺酸氨氯地平与替米沙坦联合吲达帕胺缓释片均能使患者的血压明显下降,但替米沙坦联合苯磺酸氨氯地平的血压达标率更高,MBPS的控制率更佳,其不良反应小,安全性高,是治疗晨峰高血压的理想方案,值得在临床中推广。Objective To observe the clinical efficacy of telmisartan and amlodipine besylate for the treatment of morning blood pressure surge. Methods A total of 100 hypertensive patients,who were received from August 2012 to June 2013,were randomly divided into two groups：treatment group and control group,50 cases in each group. The treatment group was administrated with 80 mg telmisartan before sleep and 5 mg amlodipine besylate in the morning;while the control group took 80 mg telmisartan and1.5 mg indapamide in the morning. Results After treatment,the 24 h mean blood pressure,daytime mean blood pressure and nighttime mea blood pressure in both groups delined obviously than those before treatment with statistically significant difference（P〈0.05）;the difference value of systolic blood pressure in both groups after treatment decreased significantly than those before treatment;the control rate of morning blood pressure surge（MBPS） was 88% in the treatment group and 56% in the control group,the difference between the two groups had statistical significance（P〈0.05）. Conclusion Either telmisartan combined with amlodipine besylate or with indapamide is effective on blood pressure control,but the telmisartan with amlodipine besylate has a higher standard-reaching rate,better control rate of MBPS,little adverse reaction and high safety,it is an ideal treatment protocol,so it is worthy of promotion and popularization in clinic.

关 键 词：苯甲酸盐类 苯咪唑类 氨氯地平 苯磺酸盐类 高血压 药物疗法 联合 治疗结果 

分 类 号：R544.1[医药卫生—心血管疾病]