黄芩苷固体自乳化颗粒剂的制备  

Preparation of Baicalin Solid Self-emulsifying Granules

作　　者：高永艳[1] 陈海文[1] 梁超峰 

机构地区：[1]广东省中医院药学部,广东广州510370 [2]广州医药研究总院有限公司,广东广州510240

出　　处：《中国医药导报》2014年第19期96-99,共4页China Medical Herald

基　　金：广东省广州市科研条件建设项目(项目编号:穗科信字[2012]224-10号);广东省广州市海珠区科技计划项目(编号2011-KG-05)

摘　　要：目的研究黄芩苷固体自乳化颗粒剂的制备工艺。方法通过溶解度考察、伪三元相图的绘制及L9(33)正交试验,以形成自乳化效果、自乳化时间和粒径的大小为指标,选择最佳自乳化处方。通过对固体吸附材料的筛选,累积溶出度的测定,筛选黄芩苷固体自乳化颗粒的最佳处方。结果最佳处方油酸乙酯-吐温(Tween)80-聚乙二醇(PEG)400的质量比为2∶7∶6,可溶性淀粉与黄芩苷固体自乳化释药系统(S-SEDDS)的质量比为4∶1,45min溶出度达102.89%。结论黄芩苷S-SEDDS制备方法简单,稳定性好,可以提高药物的溶出度。Objective To study the Baicalin Solid Self-emulsifying Granules preparation process. Methods Investigated by solubility, drawing pseudo-ternary phase diagram, and L9（33） orthogonal experiment was given, to form a self-emulsifying effect of self-emulsification time and particle size as indicator to select the best self-emulsifying prescription.Through the screening of the solid adsorbent material, and the determination of cumulative dissolution, the Baicalin solid self-emulsifying particles prescription was screened. Results The optimization of the best prescription for oleic acid ethyl ester-Tween 80-PEG400 was 2∶7∶6. Soluble starch and Baicalin S-SEDDS the mass ratio of 4∶1, dissolution was102.89% in 45 min. Conclusion Baicalin S-SEDDS is easy to prepare and its quality is stable. The dissolution of Baicalin S-SEDDS is improved.

关 键 词：黄芩苷 固体自乳化给药系统 制备 

分 类 号：TQ461[化学工程—制药化工]