凝集素样氧化型低密度脂蛋白受体水平与冠状动脉支架植入术后再狭窄的关系  

Relationship between serum LOX-1 level and intracoronary in-stent restenosis

作　　者：闫杰[1] 刁增利[1] 赵红[1] 苏鹏宇[1] 王志军[1] 葛庆锋[1] 

机构地区：[1]河北联合大学附属医院心内科,河北唐山063000

出　　处：《中国医药导报》2014年第19期137-140,共4页China Medical Herald

基　　金：河北省唐山市科技计划项目(编号13130256z)

摘　　要：目的探讨血清凝集素样氧化型低密度脂蛋白受体（LOX-1）水平与冠状动脉支架植入后再狭窄的相关性。方法选取2009年1月～2012年10月在河北联合大学附属医院行冠状动脉支架植入术,并于术后1年复查冠状动脉造影的患者382例,以支架植入段内径狭窄≥50%为再狭窄,分为再狭窄组（71例）和对照组（311例）,所有患者均于造影前采空腹血,测定血清中LOX-1水平。结果再狭窄组的血清LOX-1水平为（236.69±20.19）μg/L,明显高于对照组[（215.55±14.86）μg/L],差异有高度统计学意义（P〈0.01）。多因素Logistic回归分析显示,LOX-1是支架内再狭窄的独立危险因素（OR=1.082）。结论血清中LOX-1水平升高与冠状动脉支架内再狭窄明显相关,是冠状动脉支架内再狭窄的危险因素之一。Objective To investigate the association between serum LOX-1 level and coronary in-stent restenosis.Methods 382 patients received PCI were selected from January 2009 to October 2012 who were hospitalized in Affiliated Hospital of Hebei United University. Coronary angiography were reperformed on 12 months after PCI. Coronary in-stent restenosis was defined as eaqual to or greater than 50% of luminal diameter narrowing in coronary stent. According to the results of coronary angiography, 382 patients were divided into two groups： restenosis group（71 patients）,control group（311 patients）. Venous blood samples were drawn before coronary angiography to measure the serum LOX-1 level. Results The serum LOX-1 level in restenosis group [（236.69±20.19） μg/L] was significantly higher than that in control group [（215.55±14.86） μg/L], with significant differences（P〈0.01）. Multifactor logistic regression analysis demonstrated that high level of serum LOX-1 was an independent risk factor of coronary in-stent restenosis（OR =1.082）. Conclusion Higher serum LOX-1 level is correlated with coronary in-stent restenosis, which is an independent risk factor to coronary in-stent restenosis.

关 键 词：凝集素样氧化型低密度脂蛋白受体 支架 冠状动脉再狭窄 

分 类 号：R972.6[医药卫生—药品]