补益肺肾、祛风化痰法治疗慢性持续期哮喘的临床研究  

Therapeutic Effect and Mechanism on Tonifying Lung and Kidney and Eliminating Wind and Resolving Phlegm Treating Chronic Persistent Asthma

作　　者：王志英[1] 周学平[1] 李国春[1] 徐立然[2] 许立[1] 郭立中[1] 金路[1] 杨继兵[1] 蔡敏[3] 朱佳[4] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210023 [2]河南中医学院第一附属医院,河南郑州450000 [3]昆山市中医院呼吸科,江苏昆山215300 [4]南京中医药大学附属医院,江苏南京210029

出　　处：《南京中医药大学学报》2014年第4期316-319,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家"十一五"科技支撑计划(2007BAI10B02-03)

摘　　要：目的观察根据补益肺肾、祛风化痰法研制的温养化痰方、清养化痰方治疗慢性持续期哮喘的临床疗效及其作用机理。方法采用多中心、队列研究方案,将哮喘缓解期患者121例（名中医组队列）根据寒哮、热哮的不同,分别给予温养化痰方和清养化痰方,并与常规中医治疗的81例（常规组队列）对照,对照组分别给予固本咳喘汤和麦味地黄汤。并检测血清免疫球蛋白E（IgE）、嗜酸性粒细胞阳离子蛋白（ECP）、白细胞介素4（IL-4）、γ-干扰素（IFN-γ）水平。结果寒哮、热哮的名中医组分别与常规治疗组比较,临床控制显效率有显著性差异（P〈0.01）;血清ECP、IgE治疗后下降,其中寒哮、热哮名中医组和常规组治疗前后的比较均有显著性差异（P〈0.05～0.01）,治疗后热哮名中医组优于常规组（P〈0.05～0.01）;IL-4经治疗后数值下降,寒哮、热哮名中医组治疗前后的比较有显著性差异（P〈0.05～0.01）。IFN-γ治疗后各组数值增高（P〈0.01）,寒哮名中医组与常规组比较有显著性差异（P〈0.01）。结论名中医方虚实兼顾的治疗方案具有良好的疗效,优于单纯以补益为法的常规中医组。OBJECTIVE To observe therapeutic effect and mechanism on Wenyang Huatan Fang and Qingyang Huatan Fang based on tonifying lung and kidney and eliminating wind and resolving phlegm in treating chronic persistent asthma.METHODS 121 patients with remission asthma（named TCM cohort）were respectively given Wenyang Huatan Fang and Qingyang Huatan Fang according to cold asthma and hot asthma with multicenter and cohort study program.81cases（conventional group）with conventional treatment were taken as the control group and treated with Guben Kechuan decoction and Maiwei Dihuang decoction.IgE,ECP,IL-4,IFN-γin serum was detected.RESULTS Comparing cold asthma and hot asthma among cohorts,efficiency rate of clinical control showed significant difference（P〈0.01）.After treatment,ECP and IgE in serum decreased and the changes in both groups before and after treatment showed significant differences（P〈0.05～0.01）;IL-4reduced and cold asthma and hot asthma TCM cohorts showed significant differences（P〈0.05～0.01）;IFN-γincreased and there was a significant difference in cold asthma groups（P〈0.01）.CONCLUSION TCM cohort taking deficiency and excess into consideration has a good effect,and is superior to conventional group simply with tonifying function.

关 键 词：支气管哮喘 补益肺肾 祛风化痰 防治复发 队列研究 

分 类 号：R256.12[医药卫生—中医内科学]