定量超声检测的跟骨骨密度与代谢综合征的关系  

The relationship between calcaneus bone mineral density and metabolic syndrome

作　　者：孙启虹 巴建明[2] 陈康[2] 闫文华[2] 王先令[2] 谷伟军[2] 汪保安[2] 王健松[3] 王淑梅[4] 东黎光 伍宁玲 吕朝晖 窦京涛 母义明 

机构地区：[1]辽宁省抚顺市中医院内科,113008 [2] 解放军总医院内分泌科, 北京100853 [3] 北京大学首钢医院 [4]北京高血压联盟研究所

出　　处：《中华内科杂志》2014年第7期542-545,共4页Chinese Journal of Internal Medicine

摘　　要：目的 探索定量超声检测跟骨骨密度（BMD）与代谢综合征（MS）及其各组分之间的关系.方法 横断面研究,对象为北京某社区常住居民.按性别、绝经与否分组,每组再分为MS和非MS组,分析MS对BMD的影响.MS采用中华医学会糖尿病学分会制定的诊断标准.结果 5 552例受试者纳入分析.男女比例1：1.8,年龄40～87岁,其中,男1 987例,年龄（59.4±7.3）岁;女3 565例,年龄（56.9±7.2）岁,绝经前后女性比例1：3.7.MS患病率：男29.0％,女24.4％.协方差分析显示,MS组与非MS组BMD差异无统计学意义.但是随着MS组分数目由0个增加至4个,绝经后女性BMD有增加的趋势,协方差分析显示,BMD的增加有统计学意义（P＜0.05）.多元线性回归分析提示绝经后女性MS组的BMD与年龄呈负相关（β=-0.034,P＜0.001）、与BMI（β=0.046,P=0.001）、收缩压（β =0.007,P=0.039）、TG（β=0.066,P=0.034）呈正相关.结论 随着MS组分数目的增加,绝经后女性BMD有增加的趋势,BMD与BMI、收缩压、TG呈正相关.Objective To evaluate the association between calcaneus bone mineral density （BMD） and metabolic syndrome （MS）.Methods A cross-sectional study was carried out in 5 552 subjects with 1 987 men and 3 565 women （age：40-87 years old）.MS was defined according to Chinese Diabetes Society criteria.BMD was assessed by quantitative ultrasound.Results The proportion of MS was 29.0% in male and 24.4% in female.There were no differences in BMD between MS and non-MS subjects in both genders.Linear trend analysis displayed that BMD was positively associated with the increase of MS components in post-menopausal women after adjustment of age,ALT,creatinine and exercises （P 〈 0.05）.Moreover,multiple regression analysis showed that BMD was inversely correlated with age （β =-0.034,P 〈 0.001） and positively correlated with BMI（β =0.046,P =0.001）,TG （β =0.066,P =0.034） and systolic blood pressure（SBP） （β =0.007,P =0.039） in post-menopausal women with MS.Conclusions BMD tended to increase with the numbers of MS components in post-menopausal women.It was positively correlated with BMI,TG and SBP in postmenopausal women with MS.

关 键 词：骨密度 定量超声 

分 类 号：R589[医药卫生—内分泌]