腺苷的免疫调节功能  

Immunoregulatory effects of adenosine

作　　者：万萍[1] 陈昊[1] 白爱平[1] 

机构地区：[1]南昌大学第一附属医院消化内科,江西省南昌市330006

出　　处：《世界华人消化杂志》2014年第17期2379-2384,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81270472;81070310;江西省青年科学家培养对象计划基金资助项目~~

摘　　要：腺苷是一种嘌呤核苷,通过与细胞膜上相应的G蛋白耦联受体(A1、A2A、A2B和A3)结合,调节免疫细胞(中性粒细胞、巨噬细胞与树突细胞及淋巴细胞等)的分化成熟与迁移及细胞因子、趋化因子的释放,从而调节局部与全身炎症反应.选择性腺苷受体激动剂与拮抗剂的出现,加深了人类对腺苷的免疫调节功能及腺苷与疾病关系的认识.本文介绍了腺苷在体内的代谢过程及其通过与相应受体结合调节各种免疫细胞的功能及疾病的发病.Adenosine, a purine nucleoside, is involved in local and systemic inflammatory responses. Adenosine plays a pivotal role in the modulation of differentiation, maturation and migration of immune cells （neutrophils, macrophages, dendritic cells, lymphocytes, etc.）, as well as in the secretion of cytokines and chemokines by activating four G proteincoupled receptors （A1, A2A, A2B, and A3） which are expressed by a variety of immune cells. The development of selective agonists and antagonists of adenosine receptors has advanced the current understanding on the multiple functions of adenosine in immunologic responses and related diseases. This article reviews the metabolism of adenosine and its effects on immune ceils and inflammatory diseases via adenosine receptors.

关 键 词：腺苷 免疫细胞 免疫调节 

分 类 号：R392[医药卫生—免疫学]