强化调脂对动脉粥样硬化斑块的影响  

Influence of strengthening adjustment of fat on atherosclerosis plaque

作　　者：黄建军 王显志[2] 

机构地区：[1]崇州崇仁医院内科,四川成都611230 [2]遂宁市中心医院医学影像科

出　　处：《中国民康医学》2014年第12期9-10,49,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨强化调脂对动脉粥样硬化斑块的影响。方法:对96例经颈部血管彩色超声多普勒检查确诊为颈动脉粥样硬化斑块形成的患者为研究对象。随机分为强化调脂组和调脂组。调脂组患者进行为期8周的治疗性生活方式改变(TLC)及辛伐他汀口服;强化调脂组患者进行为期8周改进的治疗性生活方式改变(改进TLC)及辛伐他汀、维生素C口服。治疗前后采用高分辨率彩色超声多普勒观察患者颈动脉结构及血流情况,并测定颈动脉内膜-中层厚度(IMT)及血流频谱、血脂等项目,与治疗前作对照分析。结果:两组病例经治疗8周后,调脂组患者颈动脉彩超结果(颈动脉IMT、颈动脉血流的Vmax、RI、PI)与治疗前比较,差异无显著性(P>0.05),血脂检测结果 TC、TG、LDL-C均有下降(t=2.21、2.56、3.34,P<0.01),HDL-C无显著性差异(t=1.42,P>0.05)。强化调脂组患者颈动脉彩超结果(颈动脉IMT)变薄,有显著性差异(t=3.30,P<0.05),而该组颈动脉血流的Vmax、RI、PI与治疗前比较,差异无显著性(P>0.05);另外,强化调脂组患者的TC、TG、LDL-C有显著性下降(t=4.38、3.51、5.23,P<0.01),HDL-C无显著性差异(t=1.19,P>0.05)。结论:强化调脂是治疗动脉粥样硬化安全可靠的一种方案。Objective：To discuss influence of strengthening adjustment of fat on atherosclerosis plaque. Methods：96 cases with carotid atherosclerosis plaque diagnosed with color Doppler imaging for cervical vessels were selected as the research subjects and randomly divided into strengthening adjustment of fat group and adjustment of fat group; The cases in adjustment of fat group were given the therapeutic life-style change （TLC） and orally took simvastatin for 8 weeks, whereas those in adjustment of fat group were given improved （improved TLC） and orally took simvastatin and vitamin C for 8 weeks. Before and after the treatment, carotid artery struc-ture and the blood stream situation were observed by the high resolution color Doppler imaging, and intima-media thickness （IMT）, blood stream frequency spectrum, blood fat and the like were determined and compared. Results： The differences of the results of the color Doppler imaging for carotid artery （carotid artery IMT, and carotid artery blood stream Vmax, RI, and PI） of adjustment of fat group before and after the treatment were not significant （P〉0. 05）, while the blood fat examination showed that TC, TG, and LDL-C all decreased after the treatment （t=2. 21, 2. 56, 3. 34, P〈0. 01）, and the difference of HDL-C before and after the treatment was not significant （t=1. 42, P〉0. 05）. For the strengthening adjustment of fat group, the color Doppler imaging for carotid artery showed that IMT became thin, and the difference before and after the treatment was significant （t=3. 30, P〈0. 05）, but the differences of the blood stream Vmax, RI, and PI before and after the treatment were not significant （P〉0. 05）; the blood fat examination showed that TC, TG, and LDL-C all significantly decreased after the treatment （t=4. 38, 3. 51, 5. 23, P〈0. 01）, but the difference of HDL-C before and after the treatment was not significant （t=1. 19, P〉0. 05）. Conclusions： The strengthening adjustment of fat is a safe and treatment pr

关 键 词：调脂 治疗性生活方式改变 动脉粥样硬化 内膜-中层厚度 辛伐他汀 

分 类 号：R543.5[医药卫生—心血管疾病]