头孢唑肟钠在不同浓度氯化钠、氯化钾水溶液中的焓相互作用  

Enthalpic Interaction of Ceftizoxime Sodium in Aqueous Sodium Chloride and Potassium Chloride solutions at Different Concentrations

作　　者：王春梅[1] 李广乾[1] 刘敏[1] 

机构地区：[1]聊城大学化学化工学院,山东聊城252059

出　　处：《聊城大学学报（自然科学版）》2014年第2期43-51,共9页Journal of Liaocheng University:Natural Science Edition

基　　金：国家自然科学基金(21103079)

摘　　要：药物在拟生命体液中热力学性质的研究有利于阐明药物在人体内发挥药效的机理.通过等温滴定微量热法测定抗生素类药物头孢唑肟钠在298.15K下于纯水及两种盐溶液(NaCl、KCl,0.1000-0.6000mol·Kg-1)中的稀释焓,利用多元线性回归拟合得到各级同系焓相互作用系数(h2,h3,h4).拟合数据显示,头孢唑肟钠在氯化钠、氯化钾两种盐溶液中的焓对作用系数h2均为负值,并且随着盐溶液浓度的增加而减小.头孢唑肟钠在氯化钠溶液中的h2小于氯化钾溶液.通过溶剂化的溶质分子之间的相互作用分析结果并作出合理解释.The investigation of the thermodynamic properties of drugs in the simulated body fluid is benefi- cial to understand the mechanism of drugs exerting curative effects in human body. The dilution enthalpies of ceftizoxime sodium in water and two kinds of salt solution （NaC1, KC1, 0. 100 0-0. 600 0 mol·Kg-1 ） were measured by isothermal titration calorimetry at the temperature of 298. 15 K. The homogeneous enthalpic interaction coefficients （h2, h3, h4） were calculated through multiple linear regression fitting. The results showed that the enthalpic pairwise interaction coefficients h2 of ceftizoxime sodium are all negative and reduce with in- creasing concenteation of salt solution. The value of h2 in aqueous sodium chloride solutions is smaller than that in aqueous potassium chloride solutions of the same molality. The results were analyzed and a reasonable expla- nation was made through the interactions between solvated solute molecules.

关 键 词：等温滴定微量热法 焓相互作用系数 头孢唑肟钠 拟生命体液 

分 类 号：O642[理学—物理化学]