缺血性脑卒中患者TC/HDL-C、TG/HDL-C比值与HDL亚类分布的关系  

Relationship between HDL subclasses and TC/HDL-C,TG/HDL-C ratio in Ischemic Stroke

作　　者：韩瑛[1,2] 陈志军[3] 卢新华[1,2] 邓华菲[1] 王岐本[2] 孙陶利[1,2] 龙石银[4] 田英[4] 

机构地区：[1]湘南学院基础医学部 [2]湘南学院南岭药用资源研究所 [3]郴州市第一人民医院病理诊断中心,湖南郴州423000 [4]南华大学生物化学与分子生物学教研室,湖南衡阳421001

出　　处：《湘南学院学报（医学版）》2014年第2期1-4,共4页Journal of Xiangnan University（Medical Sciences）

基　　金：湖南省教育厅科研重点项目(12A127);湖南省卫生厅科研项目(B2012-74);湘南学院科研课题(2013YJ46)

摘　　要：目的探讨缺血性脑卒中患者总胆固醇/高密度脂蛋白醇(TC/HDL-C)、甘油三酯/高密度脂蛋白醇(TG/HDL-C)比值与与血浆中高密度脂蛋白(HDL)亚类含量的关系。方法根据TC/HDL-C和TG/HDL-C比值分别将61例缺血性脑卒中患者分为高、中、低比值组,采用双向电泳-免疫印迹检测法分析HDL亚类的组成、含量及分布特征。结果在缺血性脑卒中患者中,随着TC/HDL-C或TG/HDL-C比值增大,小颗粒的preβ_1-HDL含量呈升高趋势,大颗粒的HDL_(2a)、HDL_(2b)含量呈降低趋势。相关性分析发现,缺血性脑卒中患者血浆TG、TC/HDL-C和TG/HDL-C与小颗粒preβ_1-HDL含量呈正相关(P<0.05),而与大颗粒HDL_(2a)及HDL_(2b)含量呈负相关(P<0.05);HDL-C和apoA1与HDL各亚类呈正相关(P<0.05)。结论缺血性脑卒中患者中TC/HDL-C或TG/HDL-C比值的升高与HDL成熟代谢受阻、胆固醇逆转运作用减弱有关。Objective To investigate the relationship between HDL subclasses and TC/HDL-C ,TG/HDL-C ratio in ischemic stroke patients .Methods According to the ratio of TC/HDL-C and TG/HDL-C ,61 ischemic stroke patients were divided into three groups ,respectively .HDL subclasses were quantitated by two-dimension-al gel electrophoresis .Results Accompanied with the increase of TC/HDL-C and TG/HDL-C ratio in ischemic stroke patients ,the levels of small-sized preβ1 -HDL showed a trend of rise ,and the contents of large-sized of HDL2a and HDL2b showed a trend of decrease .Analysis of correlation found that TG ,TC/HDL-C and TG/HDL-C showed a positive correlation with small-sized preβ1 -HDL （ P 〈0 .05 ） ,but a negative correlation with large-sized HDL2a and HDL2b （ P 〈0 .05） ,HDL-C showed a positive correlation with all particles of HDL in isch-emic stroke patients （ P 〈0 .05 ） . Conclusion The increase of TC/HDL -C and TG/HDL -C were associated with the mature of HDL metabolism and the weakened of reverse cholesterol transport .

关 键 词：缺血性脑卒中 甘油三酯 胆固醇 高密度脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]