女童泌尿生殖道感染病原学及药敏分析  

Analysis of pathogens and drug sensitivity in female children with urogenital tract infection

作　　者：杨年娣[1] 张红爱[2] 曾翔明[1] 胡瑞娟[1] 孙峰[1] 

机构地区：[1]空军工程大学航空航天学院门诊部,西安710038 [2]西安市儿童医院新生儿科,710003

出　　处：《检验医学与临床》2014年第A01期43-44,共2页Laboratory Medicine and Clinic

摘　　要：目的了解该地区女童泌尿生殖道感染病原学及药敏情况，为临床合理用药提供科学依据。方法采用实时荧光定量PCR方法对692例女童泌尿生殖道标本进行淋球菌（NGH）、沙眼衣原体（CT）、解脲支原体（UU）检测；采用珠海银科生物工程有限公司支原体药敏试剂盒观察10种抗菌药物的体外药物敏感性。结果此692例女童NGH阳性34例，阳性率4．9％（34／692）；CT阳性32例，阳性率4．6％（32／692）；UU阳性106例，阳性率15．3％（106／692）；CT与UU同时阳9例，阳性率1．3％（9／692）。UU阳性率与CT、NGH阳性率差异有统计学意义（P〈0．05）；药敏试验结果表明支原体对交沙霉素、强力霉素、美满霉素、克拉霉素的耐药性较低，分别为3．7％、6．6％、7．5oA、16．9％。结论女童泌尿生殖道感染以UU为主；该地区治疗女童支原体感染的药物首选交沙霉素、克拉霉素；实时荧光定量PCR方法检测有助于临床早期快速检查阴道分泌物中UU、NGH和CT。Objective To investigate distribution of the pathogens and drug resistance in female children with urogenital tract infection and provide scientific basis for clinical. Methods Neisseria gonorrhoeae（NGH） ,Chlamydia trachomatis（CT） and ureaplasma urealyticum（UU） which been collected from 692 cases female children with urogenital tract infection were tested by real-time PCR. Drug sensitivity test in vitro adopted Mycoplasma susceptibility kits which Belong to Zhuhai silver branch biological engineering co. ,LTD. Results The positive rate of NGH was 4.9 % （34/692） ,CT was 4.6%（32/692） ,UU was 15.3%（106/692） ,UU＋CT was 1.3%（9/692） ,The difference was sta- tistically significant（P〈0.05）. The drug resistant rates of UU to josamycin,doxycycline,minocycline and clarithro- mycin were 3.7 %, 6.6 %, 7.7 %, 16.9 %. Conclusion Urogenital tract infection in female children was mainly due to UU infection;josamycin and clarithronmycin were the first choices for treatment of UU infection, real-time PCR method tested UU, NGHand CT has helpful for quick diagnosis of the disease in clinic.

关 键 词：女童 泌尿生殖道 病原学 药敏分析 

分 类 号：R691.3[医药卫生—泌尿科学]