美洛西林钠舒巴坦对肺炎患者的治疗机制研究  

Study on the treatment mechanism of pneumonia with Meziocillin sodium and Sulbactam sodium

作　　者：张玉敏 

机构地区：[1]河南省南阳市桐柏县第二人民医院内科,474750

出　　处：《检验医学与临床》2014年第A01期76-78,共3页Laboratory Medicine and Clinic

摘　　要：目的探究美洛西林钠舒巴坦对肺炎患者的治疗效果以及作用机制。方法将2012年2月至2014年2月将收治的164例肺炎患者平均随机分为两组，每组各82例。研究组采用美洛西林钠舒巴坦进行静脉滴注，对照组采用美洛西林钠进行静脉滴注，2周后比较两组患者的治疗有效情况、临床体征和不良反应。结果2周后，研究组患者治疗全部有效，即有效率达100％，同时77例痊愈，痊愈率高达93．9％；对照组患者治疗全部有效，即有效率达100％，同时30例痊愈，痊愈率仅有36．6％，两组差异有统计学意义（x2=13．35，P=0．0012〈0．05）。并且，研究组患者的临床体征消失的平均时间早于对照组，差异有统计学意义（P〈0．05）。在不良反应方面，研究组出现2例，不良反应率为2．4％；对照组出现10例，不良反应率高达12．2％，差异有统计学意义（t=6．35，P=0．0057〈0．05）。结论相对于美洛西林钠，美洛西林钠舒巴坦更能较快、较好地治疗肺炎，并且其不良反应小，值得在临床上进行合理应用。Objective To explore the therapeutic effect and mechanism of mezlocillin sodium,sulbactam in patients with pneumonia. Methods From February 2012 to February 2014,164 cases of pneumonia patients were randomly divided into two groups,82 patients in each group. The study group were treated with mezlocillin sodium and sulbactam for intravenous drip,and the control group were treated with mezlocillin sodium intravenous injection. After 2 weeks, compared two groups of patients with effective treatment, clinical symptoms and adverse reaction. Results After 2 weeks,patients in the study group were all better with the effective rate was 100%, as 77 people heal, cure rate was as high as 93.9 % ; patients in the control group were all better, as the effective rate was 100 %, and 30 recovered, recovery rate of only 36.6 %, the difference between two groups was significant（x2 = 13.35, P = 0. 001 2〈0.05）. In addition, the clinical symptoms of patients in the study group disappeared earlier than that of the control group,the difference was statistically signifieant（P〈0. 05）. Two eases in the study group appeared the adverse effect as the ratio was 2.4 % ; 10 cases in the control group appeared the adverse effect, the ratio was as high as 12.2 %, and the difference was statistically significant （t = 6.35, P = 0. 005 7〈 0. 05 ）. Conclusion Compared with mezlocillin sodium,mezlocillin sodium and sulbaetam could cure pneumonia more quickly,and less adverse reactions appear, so it is worth to using rationally in clinical application.

关 键 词：美洛西林钠 舒巴坦 肺炎 

分 类 号：R978.11[医药卫生—药品]