心脏型脂肪酸结合蛋白对早期急性心肌梗死的诊断价值  

Value of heart-type fatty acid-binding protein for early diagnosis of acute myocardial infarction

作　　者：蔡朝民[1] 彭运生[1] 程明刚[1] 刘香萍[1] 徐羽忠 叶国强[1] 

机构地区：[1]广东省深圳市宝安区人民医院检验科,广东深圳518101

出　　处：《国际检验医学杂志》2014年第13期1718-1719,1721,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨心脏型脂肪酸结合蛋白在早期急性心肌梗死中的诊断价值。方法收集因"胸痛、胸闷3h以内"就诊,拟诊为急性心肌梗死患者186例,检测所有入选者的血浆肌酸磷酸激酶同工酶(CK-MB)、肌钙蛋白-I(CTn-I)和心脏型脂肪酸结合蛋白(H-FABP)。比较3种指标对早期急性心肌梗死诊断的敏感性和特异性。结果与非心肌梗死组和对照组相比,急性心肌梗死组患者血浆CK-MB、CTn-I及H-FABP明显升高(P<0.05);与CK-MB和CTn-I相比,H-FABP对3h以内的急性心肌梗死诊断的敏感性较高,而特异性则低于CTn-I,但高于CK-MB。结论对于发病3h内的急性心肌梗死患者,检测H-FABP可以在一定程度上提高对早期急性心肌梗死的诊断率。Objective To investigate the value of heart-type fatty acid-binding protein in the diagnosis of early myocardial infarc-tion.Methods In 186 cases of suspected acute myocardial infarction due to ＂chest pain,chest tightness＂ for 3 h,plasma CK-MB, troponin-I（CTn-I）and heart-type fatty acid-binding protein（H-FABP）were detected.The sensitivity and specificity in diagnosing early myocardial infarction were compared among 3 kinds of indexes.Results Compared with the non-infarction group and the con-trol group,plasma CK-MB,CTn-I and H-FABP in the acute myocardial infarction group were significantly increased （P 〈0.05 ）;compared with CK-MB and CTn-I,the sensitivity of H-FABP to the diagnosis of acute myocardial infarction within 3 h was higher, but its specificity was lower than that of CTn-I and higher than that of CK-MB.Conclusion For the patients with acute myocardial infarction within 3 h after onset,detecting H-FABP can increase the diagnostic rate of early myocardial infarction to a certain extent.

关 键 词：心脏型脂肪酸结合蛋白 心肌梗死 肌钙蛋白I 

分 类 号：R542.22[医药卫生—心血管疾病]