HBeAg阴性慢性乙型肝炎患者血清胱抑素C水平及其临床价值  

Level and clinical value of serum cystain C in patients with HBeAg-negative chronic hepatitis B

作　　者：王晓亮[1] 唐生尧 刘国生[1] 周维[1] 郑建琼[1] 周发为[1] 

机构地区：[1]湖北民族学院附属民大医院检验科,湖北恩施445000

出　　处：《国际检验医学杂志》2014年第13期1729-1731,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨乙型肝炎病毒e抗原(HBeAg)阴性慢胜乙型肝炎(CHB)患者血清胱抑素C(CysC)水平变化及其临床价值。方法选取在该院就诊的212例CHB患者,根据HBeAg特点分为阴性组和阳性组,选取105例健康者作为对照组,检测血清CysC、ALT、AST、Cr、BUN、HBV DNA水平。Pearson相关分析法判断HBeAg阴性CHB患者CysC与ALT、AST、Cr、BUN、HBV DNA水平的相关性。结果 HBeAg阴性CHB患者组的CysC水平(1.40±0.36)mg/L高于对照组(0.93±0.12)mg/L和HBeAg阳性CHB患者组(0.96±0.18)mg/L,差异有统计学意义(P<0.05);HBeAg阴性CHB患者组的CysC水平与肾功能的Cr水平呈明显的正相关(r=0.840,P<0.01)。结论 CysC可作为监测HBeAg阴性CHB患者的早期肾损害的有效指标,对疾病的防治有重要的临床意义。Objective To investigate the change and clinical value of serum cystain C（CysC）level in the patients with HBeAg-negative chronic hepatitis B（CHB）.Methods 212 cases of CHB in our hospital were selected and divided into the HBeAg-negative group and the HBeAg-positive group according to the HBeAg status.105 healthy individuals at the same time were enrolled as the control group.The levels of serum CysC,ALT,AST,Cr,BUN and HBV DNA in 3 groups were detected and compared.The corre-lations between serum CysC with AST,AST,Cr,Bun,HBV DNA were analyzed by the Pearson correlation analysis.Results The mean CysC level in the HBeAg-negative group was （1 .40±0.36）mg/L,which was higher than （0.93±0.12）mg/L in the control group and （0.96±0.18）mg/L in the HBeAg-positive group,the differences between them was statistically significant（P 〈0.05）. The CysC was significantly positively correlated with serum Cr level in the HBeAg-negative group（r=0.840,P 〈0.01）.Conclusion The CysC level might be used as an effective index for monitoring the early kidney injury in the patients with HBeAg-negative CHB,which has important significance in the prevention and treatment of HBeAg-negative CHB.

关 键 词：肝炎 乙型 慢性 半胱氨酸蛋白酶抑制剂 肾损害 

分 类 号：R512.62[医药卫生—内科学]