β-氧代酰胺衍生物的Vilsmeier反应在杂环化合物合成中的应用  

Vilsmeier Reactions of β-Oxo Amide Derivatives: Applications in the Synthesis of Heterocyclic Compounds

作　　者：梁永久[1] 黄鹏[1,2] 张睿[1] 董德文[1] 

机构地区：[1]中国科学院长春应用化学研究所,长春130022 [2]辽宁大学化学院,沈阳110036

出　　处：《有机化学》2014年第6期1037-1047,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20872136;21172211)资助项目~~

摘　　要：综述了我们研究组近几年在β-氧代酰胺化合物的Vilsmeier反应研究反面取得的进展.设计、合成了系列具有多官能化结构特点的β-氧代酰胺化合物,对其Vilsmeier反应进行了系统研究,探讨了相关反应的机理,建立了基于β-氧代酰胺化合物Vilsmeier反应的四元、五元、六元杂环化合物的合成新方法.Our recent research progress based on Vilsmeier reaction of β-oxo amide derivatives is summarized in this account. Series of functionalized β-oxo amide derivatives were designed and prepared, their reaction under the Vilsmeier reaction conditions and the mechanisms involved in these reactions were investigated. Efficient synthetic approaches for four-, five-, and six-membered heterocycles via Vilsmeier reaction of β-oxo amide derivatives had been developed.

关 键 词：β-氧代酰胺 Vilsmeier反应 杂环化合物 合成方法 

分 类 号：O626[理学—有机化学]