离子液体中钯催化合成cis-1,2-二卤代-1,7-辛二烯的反应研究  

Synthesis of cis-1,2-Dihalosubstituted 1,7-Octadienes by Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids

作　　者：杨少容[1] 凌厂围 马建业[1] 张蕾[1] 李建晓 罗维[2] 

机构地区：[1]华南理工大学化学与化工学院,广州50640 [2]华南理工大学分析测试中心,广州50640

出　　处：《有机化学》2014年第6期1148-1153,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21102047;31101221);华南理工大学学生研究计划资助项目~~

摘　　要：发展了一种以PdBr2为催化剂,以[Bmim]X/HXaq为溶剂,炔卤与5-己烯-1-醇进行交叉偶联反应的新方法,以中等及优良的产率（73%～94%）合成了系列cis-1,2-二卤代-1,7-辛二烯衍生物.反应表现出较高的区域选择性和立体选择性.并且该偶联反应合成途径简捷、反应条件温和,可为cis-1,2-二卤代烯烃类化合物的合成提供简便的途径.A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of haloalkynes with hex-5-en-1-ol in ionic liquids. In the presence of PdBr2, [Bmim]X and HXaq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio- and stereo-selectivities. Moreover, the reaction is a convenient and simple path for the synthesis of the cis-1,2-dihalosubstituted alkenes, and tolerates several functional groups on haloalkynes.

关 键 词：离子液体 钯催化 炔卤 5-己烯-1-醇 cis-1 2-二卤代烯烃 

分 类 号：O643.32[理学—物理化学]