IPrAuCl/AgOTf催化下合成N-磺酰基四氢吡咯类化合物  

Synthesis of N-Sulfonyl Pyrrolidines Catalyzed by IPrAuCl/AgOTf

作　　者：原东鹏 曾明[1] 柏春美[1] 崔冬梅[1] 张辰[2] 

机构地区：[1]浙江工业大学药学院 [2]浙江大学药学院,杭州30058

出　　处：《有机化学》2014年第6期1231-1234,共4页Chinese Journal of Organic Chemistry

基　　金：浙江省自然科学基金(No.Y4100558)资助项目~~

摘　　要：在IPrAuCl和AgOTf催化体系作用下,通过一系列磺酰胺和四氢呋喃类化合物反应,合成了N-磺酰基四氢吡咯类化合物,实现了五元氧杂环到氮杂环类化合物的转换.6-Bromofuro[2,3-d]pyrimidine bicyclic nucleosides are the key intermediates for the preparation of novel furo[2,3-d]pyrimidine bicyclic nucleoside derivatives with remarkable antiviral potency. The literature protocol for their synthesis involves a multi-step procedure and palladium catalyst. In this paper, an economical and practical method was developed for their preparation via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide and subsequent cyclization promoted by copper iodide.

关 键 词：磺酰胺 催化剂 四氢呋喃 四氢吡咯 

分 类 号：O626.13[理学—有机化学]