冠心病主要危险因素与血瘀证的相关性研究  

Association of Main Risk Factors with Blood Stasis Syndrome in Coronary Artery Disease

作　　者：时莉晓[1] 高铸烨[1] 杨巧宁[1] 尚青华[1] 尤士杰[1] 史大卓 

机构地区：[1]中国中医科学院西苑医院 [2]中国医学科学院阜外心血管病医院

出　　处：《中西医结合心脑血管病杂志》2014年第6期646-648,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家"重大新药创制"科技重大专项基金资助项目(No.2009ZX09502-031);中医药行业科研专项基金资助项目(No.201007001);国家科技支撑计划课题(No.2011BAZ03237)

摘　　要：目的探讨冠心病主要危险因素及相应理化指标与血瘀证的相关性。方法采用横断面研究设计,入选2011年3月—2011年7月阜外心血管病医院、安贞医院、中日友好医院及中国中医科学院西苑医院4家医院就诊的冠心病血瘀证和非血瘀证患者共319例。观察并记录四诊信息及实验室检查结果,采用二分类非条件Logistic回归及多元相关分析,探讨各因素与冠心病血瘀证的相关性。结果 Logistic回归分析显示:高血压(OR=3.942,P=0.000)、血脂异常(OR=3.054,P=0.000)、糖尿病(OR=1.871,P=0.032)、吸烟(OR=1.831,P=0.042)是血瘀证的相关因素;总胆固醇(OR=2.109,P=0.038)、低密度脂蛋白胆固醇(OR=1.598,P=0.039)、收缩压(OR=1.022,P=0.026)、吸烟量(OR=1.001,P=0.001)是冠心病血瘀证的相关临床指标;多元相关分析显示:吸烟量(r=0.282,P=0.000)、收缩压(r=0.120,P=0.033)和低密度脂蛋白胆固醇(r=0.118,P=0.036)与血瘀证计分呈正相关。结论高血压、血脂异常、糖尿病和吸烟是冠心病和血瘀证共同相关的危险因素,总胆固醇、低密度脂蛋白胆固醇、收缩压和吸烟是冠心病和血瘀证共同相关的临床指标,低密度脂蛋白胆固醇、收缩压和吸烟与血瘀证计分呈正相关。Objective To explore the correlation between blood stasis syndrome（BSS）and main risk factors as well as relevant physical and chemical indicators in patients with coronary artery disease（CAD）.Methods A total of 319patients were divided into coronary heart disease blood stasis syndrome（CAD-BSS）group and coronary heart disease non-blood stasis syndrome（CAD-nonBSS）group.Through cross-sectional survey method,clinical data were collected in detail.The correlation between factors in different categories and BSS was analyzed by binary unconditional Logistic regression analysis and multivariate correlation analysis.ResultsHypertension（OR=3.942,P=0.000）,dyslipidemia（OR=3.054,P=0.000）,diabetes mellitus（OR=1.871,P=0.032）,and smoking（OR=1.831,P=0.042）were relevant factors for BSS.Total cholesterol（OR=2.109,P=0.038）,low density lipoprotein cholesterol（OR=1.598,P=0.039）,systolic blood pressure（OR=1.022,P=0.026）,and the number of cigarettes smoked（OR= 1.001,P=0.001）were relevant clinical indicators of CAD-BSS.Low density lipoprotein cholesterol,systolic blood pressure,and the number of cigarettes smoked were positively related to BSS score.Conclusion There were common risk factors and clinical indicators in CAD and BSS.Some of clinical indicators were positively related to BSS score.

关 键 词：冠心病 血瘀证 危险因素 血瘀证计分 

分 类 号：R256.2[医药卫生—中医内科学]