动脉粥样硬化易损斑块与TLR4/NF-κB信号通路关系的研究进展  

Toll Receptor 4/NF-kB Signaling Pathway in Atherosclerotic Vulnerable Plaque

作　　者：杨俊[1] 岳增辉[1] 谢涛[1] 胡岗珠 

机构地区：[1]湖南中医药大学

出　　处：《中西医结合心脑血管病杂志》2014年第6期747-749,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金项目(No.81273860);国家重点基础研究计划(No.2014CB543102)

摘　　要：Toll受体4(TLR4)能识别多种病原相关分子模式,并能促进白细胞浸润、脂质核心的形成、纤维帽变薄、血管新生等病理过程,在动脉粥样硬化易损斑块的发生发展中的作用极其重要。TLR4能激活核转录因子(NF-κB)和促炎性蛋白,进一步促进炎症反应的发生和动脉粥样斑块的不稳定性增加。本文总结近年有关动脉粥样硬化易损斑块与TLR4/NF-κB信号通路关系的研究进展。Toll receptor 4（TLR4）can identify PAMPs,and promote leukocyte infiltration,the formation of lipid core,the thinning of the fibrous cap and angiogenesis and so on.It has a extremely important role in the development of atherosclerosis vulnerable plaque.TLR4can activate nuclear factor kappa B（NF-κB）transcription factors and proinflammatory protein,then promote the inflammatory reaction and increase the instability of atherosclerotic plaque inflammation.This review will discuss advances of the relationship between TLR4/NF-κB signaling pathway and atherosclerotic vulnerableplaque from three aspects.

关 键 词：动脉粥样硬化 Toll受体4 核转录因子 易损斑块 

分 类 号：R543.5[医药卫生—心血管疾病] R256.2[医药卫生—内科学]