卡维地洛联合阿司匹林治疗快速性心律失常疗效观察  

Efficacy of carvedilol in combination with aspirin for patients with tachyarrhythmia

作　　者：李飞[1] 冯力[1] 董剑廷[1] 孙劼[1] 曹丽娜[2] 袁勇[1] 

机构地区：[1]中山市人民医院心血管内科,广东中山528400 [2]中山市人民医院肾脏中心,广东中山528400

出　　处：《临床和实验医学杂志》2014年第14期1145-1148,共4页Journal of Clinical and Experimental Medicine

基　　金：2012年广东省医学科研基金课题;编号:A2012810

摘　　要：目的探究卡维地洛联合阿司匹林治疗快速性心律失常临床效果。方法选取快速性心律失常患者104例,随机将其分为治疗组及对照组各52例。给予对照组常规治疗方案进行治疗,治疗组在对照组治疗方案的基础上加用卡维地洛联合阿司匹林进行治疗。观察比较两组患者的超敏C反应蛋白(hs-CRP)、左室射血分数(LVEF)、急性发作期的胺碘酮用量、电复律能量、平均电复律次数、平均心率(HR)、收缩压(SBP)、治疗效果及病死率。结果治疗前两组患者的hs-CRP、LVEF、HR及SBP等比较差异无显著性(P>0.05);治疗4周后治疗组患者的hs-CRP、HR及SBP均低于对照组,LVEF明显高于对照组(P<0.05);治疗1年间治疗组患者的急性发作期的胺碘酮用量、电复律能量及平均电复律次数明显低于对照组(P<0.05)。治疗组的总有效率96.15%明显高于对照组的82.69%(P<0.05)。治疗组病死率0低于对照组的3.85%,但差异无显著性(P>0.05)。结论应用卡维地洛联合阿司匹林治疗快速性心律失常可明显改善患者临床症状,降低患者发病的抢救难度及病死率。Objective To explore the efficacy of Carvedilol in combination with aspirin for patients with tachyarrhythmia. Methods 104cases of tachyarrhythmia patients were selected. These patients were divided into treatment group（ 52 cases） and control group（ 52 cases） according to a stratified random grouping method. The patients of control group were given conventional treatment options for treatment and the patients of treatment group were given carvedilol combination with aspirin on the basis of control group. The index of patients of the two groups such as hypersensitive C-reactive protein（ hs-CRP）,left ventricular ejection fraction（ LVEF）,acute exacerbation of amiodarone dosage,electrical cardioversion energy,the average number of electrical cardioversion,the average heart rate（ HR）,systolic blood pressure（ SBP）,treatment and mortality were compared in this research. Results There were not statistically significant of hs-CRP,LVEF,HR and SBP of the two group of patients before treatment（ P 〉0. 05）. The hs-CRP,HR and SBP of treatment group were lower than those of the control group. The LVEF of treatment group was higher than that of control group after 4-week treatment（ P〈 0. 05）. The amiodarone dosage,amount of electrical cardioversion energy and average number of electrical cardioversion of treatment group was significantly lower than those of the control group during the year of treatment（ P 〈 0. 05）. The total efficiency 96. 15% in treatment group was significantly higher than that of control group（ 82. 69%）（ P 〈 0. 05）.The mortality 0 in treatment group is less than in the control group（ 3. 85%）,but the difference was not significant（ P 〉 0. 05）. Conclusion The Carvedilol combine with aspirin for patients of tachyarrhythmia can significantly improve the clinical symptoms and reduce difficulty of rescue and the mortality.

关 键 词：快速性心律失常 卡维地洛 阿司匹林 胺碘酮 

分 类 号：R541.7[医药卫生—心血管疾病]