亚临床甲状腺功能减退症患者血脂及超敏C反应蛋白变化分析  

The analysis of blood fat and high sensitive-C reactive protein in patients with subclinical hypothyroidism

作　　者：尹冬梅[1] 许敏[1] 田惠[1] 

机构地区：[1]新疆维吾尔自治区人民医院北院内分泌科,乌鲁木齐830054

出　　处：《中国医师进修杂志》2014年第19期19-21,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的分析亚临床甲状腺功能减退症患者的血脂及超敏C反应蛋白（hs—CRP）水平变化及其临床意义。方法选取50例亚临床甲状腺功能减退症患者作为观察组，另选取与其年龄及性别相匹配的50例健康体检者作为对照组，分别测定两组的血脂及hs—CRP，并进行比较。结果观察组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL—C）显著高于对照组[（5．20±0．84）mmol／L比（4．79±0．80）mmol／L、（2．21±0．97）mmol/L比（1．78±0．60）mmol／L、（3．25±0．65）mmol／L比（2．83±0．51）mmol／L]，HDL．C显著低于对照组[（1．18±0．15）mmol／L比（1．28±0．22）mmol／L]，差异均有统计学意义（P〈0．05或〈0．01）。观察组hs—CPR显著高于对照组[（4．2±1．1）mg／L比（3．0±0．8）μg／L]，差异有统计学意义（P〈0．01）。结论亚临床甲状腺功能减退症可引起TC、TG、LDL-C及hs-CRP升高，HDL—C降低，由此推断其可能加速动脉硬化和心血管疾病的发生，故对本病及时筛查及干预是必要的。Objective To analyze the change and clinical significance of blood lipid and high sensitive-C reactive protein （hs-CRP） in patients with subclinical hypothyroidism. Methods Fifty patients with subclinical hypothyroidism were selected as observation group,and 50 health people with the same gender and age were selected as control group. The blood lipid and hs-CRP levels in the two groups were measured and compared. Results The total cholesterol （TC）,triacylglycerol （TG）,and low density lipoprotein cholesterol （LDL-C） in observation group were significantly higher than those in control group [（5.20 ±0.84） mmol/L vs. （4.79 ±0.80） mmol/L, （2.21±0.97） mmol/L vs. （1.78 ±0.60） mmol/L, （3.25 ±0.65） mmol/L vs. （2.83 ±0.51） mmol/L],high density lipoprotein cholesterol （HDL-C） was significantly lower than that in control group [ （ 1.18 ± 0.15） mmol/L vs. （ 1.28 ± 0.22） mmol/L] ,and there were statistical differences （P 〈 0.05 or 〈 0.01 ）. The hs-CPR in observation group was significantly higher than that in control group [ （4.2 ±1.1 ） mg/L vs. （3.0± 0.8 ） mg/L ], and there was statistical difference （P 〈 0.01 ）. Conclusions Subclinical hypothyroidism can cause increased TC,TG, LDL-C and hs-CRP and decreased HDL-C, which may accelerate atherosclerosis and cardiovascular disease. It is necessary to timely screen and treat the disease.

关 键 词：甲状腺功能减退症 血脂异常 C反应蛋白质 动脉粥样硬化 

分 类 号：R581.2[医药卫生—内分泌]