布比卡因复合吗啡蛛网膜下腔麻醉用于肛周疾病手术的临床观察  

Clinical observation of the application of subarachnoid anesthesia with bupivacaine combined with morphine to the surgery of crissum diseases

作　　者：李鑫明 阳文誉 

机构地区：[1]桂林市中西医结合医院,广西桂林541004

出　　处：《华夏医学》2014年第3期19-21,共3页Acta Medicinae Sinica

摘　　要：目的：观察布比卡因复合吗啡用于蛛网膜下腔的安全性.方法：选择ASA Ⅰ～Ⅱ级50例肛周疾病的择期手术患者,随机分为两组,每组25例.实验组注入0.75％布比卡因1.8 ml＋吗啡0.5mg;对照组注入0.75％布比卡因1.8 ml,置入硬膜外导管注入吗啡2.0 mg.术中及术后4,6,8,12和24 h患者的HR、BP、RR、SP O2.采用视觉模拟评分（VAS）.结果：两组患者术中、术后HR、BP、RR、SPO2差异均无统计学意义（P＞0.05）.实验组在术后6,8,12和24 h的VAS评分明显低于对照组,镇痛效果优于对照组（P＜0.05）.结论：0.75％布比卡因复合0.5 mg吗啡蛛网膜下腔麻醉可安全用于肛周疾病手术的麻醉,术后镇痛效果好.Objective： To observe the safety of the application of the subarachnoid anesthesia with bupivacaine combined with morphine. Methods ： 50 patients with crissum diseases of ASA Ⅰ- Ⅱ wait ing for surgeries were randomized into 2 groups with 25 patients each. Patients in the experimental group were injected 1.8 ml bupivacaine （with the concentration of 0.75%） combined with 0.5 mg morphine; while patients in the control group were injected 1.8 ml bupivacaine（with the concentration of 0.75%）, 2 mg morphine through epidural catheter. HR, BP, RR and SPO2 of the patients during the operation and 4, 6, 8, 12 and 24 h after operation were evaluated by VAS. Results： There were no statistical difference of the HR, BP, RP and SpO2 between both groups （P〈0.05）. 6, 8, 12 and 24 h after operation, VAS in the experimental group as obviously lower than those in the control group, and the analgesic effect was superior to that of the control group （P〈0.05 or P 〈0.01）. Conclusion：Subarachnoid anaesthesia with 0.75M bupivacaine and 0.5 mg morphine can be safely used as anaesthesia for surgeries of crissum diseases, and it can provide perfect postoperative analgesia.

关 键 词：布比卡因 吗啡 镇痛 蛛网膜下腔麻醉 

分 类 号：R614.4[医药卫生—麻醉学]