鸭疫里氏杆菌病三价油乳剂灭活疫苗的研究  

Study on the inactivated oil-adjuvant trivalent vaccine against Riemerella anatipestifer infection

作　　者：胡清海[1] 刘晓文[1] 赵世华 张知良[1] 苗晋锋[1] 刘华雷[1] 赵宝华[1] 徐步[1] 丁铲[1] 

机构地区：[1]江苏省家禽科学研究所,江苏扬州225003

出　　处：《中国兽医科技》2002年第7期6-9,共4页Chinese Journal of Veterinary Science and Technology

基　　金：江苏省"九五"农业科技攻关项目 (BE9932 4 )

摘　　要：以 1、2、10型鸭疫里氏杆菌 (RA)分离株为菌种 ,研制鸭疫里氏杆菌病三价油乳剂灭活疫苗。经无菌及安全检验合格后 ,对 6日龄樱桃谷雏鸭颈部皮下接种 0 .4mL/只 ,免疫后第 10、14、2 1和 3 5d分别用 1、2、10型RA强毒株攻击 ,第 14d的攻毒保护率为 91.7%～ 10 0 % ,3 5d的攻毒保护率为 66.6%～ 83 .3 %。田间试验结果表明 ,雏鸭 5～ 7日龄免疫后至上市保护率可达 95 .0 %～ 10 0 %。The inactivated oil adjuvant trivalent vaccine against Riemerella anatipestifer infection was developed with Riemerella anatipestifer serotype 1,2,10. 6 old day ducklings were subcutaneously inoculated with the vaccine 0.4 mL at the neck. These duckings were challenged with Riemerella anatipestifer serotype 1,2,10 virulent strain on the day 10,14,21,35 postinoculation, respectively. The protective efficacies reached 91.7% to 100% on the 14th day postinoculation, and 66.6% to 83.3% on the 35th day postinoculation. The field experiment showed that the protective efficacies after inoculation at 5～7 old day reached 95% to 100% until marketing.

关 键 词：鸭疫里氏杆菌病 三价油乳剂灭活疫苗 安全性 保护率 

分 类 号：S858.325.1[农业科学—临床兽医学] S858.322.5[农业科学—兽医学]