脂质体降低尼美舒利肝脏毒性的初步研究  

The preliminary inquiry of liposomes reduce nimesulide liver toxicity

作　　者：刘聪[1] 陈新梅[1] 袁玉芳[1] 

机构地区：[1]山东中医药大学药学院,山东济南250355

出　　处：《药学研究》2014年第7期382-383,398,共3页Journal of Pharmaceutical Research

基　　金：山东中医药大学2014年SRT项目(项目编号:2014144)

摘　　要：目的考察尼美舒利脂质体对肝脏的影响作用。方法小鼠随机分为生理盐水对照组、尼美舒利溶液组及尼美舒利脂质体组,各组分别灌胃相应药物,21 d后处死并检测小鼠肝脏中ALT和AST活性,同时观察肝组织病理变化。结果 NIM溶液组小鼠与对照组小鼠相比,谷草转氨酶和谷丙转氨酶均明显升高,分别为(250.11±31.64),(234.01±29.59),P<0.01;脂质体组小鼠与溶液组相比,谷草转氨酶和谷丙转氨酶均降低,分别为(207.33±25.77),(198.44±24.70),P<0.05;小鼠肝脏病理切片显示脂质体组小鼠肝损伤程度明显低于溶液组小鼠。结论脂质体能显著降低尼美舒利的肝脏毒性。Objective To explore the influence of nimesulide liposomes to liver.Methods Methods of test animals were randomly divided into control group,nimesulide solution group and nimesulide liposome group.Each group were orally administered drugs accordingly,21 d after testing animals were sacrificed and liver tissue ALT and AST activity observed pathological changes in Liver tissue.Results The nimesutide solution group of mice was compared with the control group of mice whose serum aspartate,alanine aminotransferase were significantly increased,respectively（250.11 ± 31.64）,（234.01 ±29.59）,P 0.01; Mice with liposome and solution mice compared to their aspartate transaminase,alanine aminotransferase were low,respectively（207.33 ± 25.77）,（198.44 ± 24.70）,P 0.05; Microscopic observation of mouse liver biopsy,liver damage liposome group of mice was significantly lower extent.Conclusion Liposomes reduced liver toxicity nimesulide.

关 键 词：尼美舒利 脂质体 肝脏保护 

分 类 号：R965[医药卫生—药理学]