淋滞疏通方治疗腹水型晚期血吸虫病312例效果观察  

The effect observation on 312 cases with advanced schistosomiasis ascites treated by Linzhishutong

作　　者：王友斌[1] 徐肇纲 贺正文[1] 曹淳力[2] 

机构地区：[1]公安县疾病预防控制中心血吸虫病预防所,湖北公安县434300 [2]中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾,血吸虫病和丝虫病合作中心

出　　处：《热带病与寄生虫学》2014年第2期83-84,119,共3页Journal of Tropical Diseases and Parasitology

摘　　要：目的探索使用中药治疗腹水型晚期血吸虫病的效果。方法将312名腹水型晚期血吸虫病患者随机分成观察组和对照组,每组各156例。观察组的治疗药物为淋滞疏通方,对照组使用安体舒通和速尿注射液。治疗结束后观察腹水消退和复发情况。结果 312例患者中,男性患者236例,女性患者76例;年龄8~79岁,平均年龄55.28岁。治疗后,观察组临床治疗总有效率为93.59%(146/156),对照组为74.36%(116/156),两组差异具有统计学意义(x^2=21.435,P<0.05)。观察组腹水消退时间少于对照组患者。观察组患者腹水复发率为27.52%(30/109),对照组为66.29%(59/89),两组差异具有统计学意义(x^2=29.760,P<0.05)。观察组患者副反应发生率为7.05%(11/156),对照组患者副反应发生率为94.86%(148/156),两组的差异具有统计学意义(x^2=240.717,P<0.05)。结论淋滞疏通方可作为腹水治疗药物在临床应用。Objective To evaluate the effect of Linzhishutong on the patients with advanced schistosomiasis ascites. Methods 312 advanced schistosomiasis ascites patients were randomly divided into trial group and control group, and each group with 156 cases. The patients in trial group were treated with chinese medicine Linzhishutong, and the patients in control group were treated with Antisterone and Furosemide injection. After treatment, the situations of ascites degrade and relapses were observed. Results Fou the 312 cases, the male was 236 and female was 76, the age range was from 8 to 79 years old, and the average age was 55.28. After treatment, the rate of general effective in trial group and control group was 93.59%（146/156）and 74.36%（116/156）, respectively. There was significant differences（χ^2=21.435, P〈0.05）between the two groups. The ascites degrade time in the trial group was less than that in the control group. The ascites relapse rate in the trial group was 27.52%（30/109）,and 66.29%（59/89） in the control group, and also there was significant differences（χ^2=29.760, P〈0.05）between the two groups. The side-effect rate in the trial group and control group was 7.05%（11/156） and 94.86%（148/156）, respectively, with significant differences（χ^2=240.717, P〈0.05）between the two groups. Conclusions Linzhishutong is an optional chinese medicine for the clinical treatment to advanced schistosomiasis ascites.

关 键 词：晚期血吸虫病 腹水 治疗 效果 

分 类 号：R532.21[医药卫生—内科学]