回顾性分析阿奇霉素联合小儿消积止咳口服液治疗支原体肺炎的临床疗效  

Retrospective analysis of clinical efficacy of zithromax combined with Xiaoer Xiaoji Zhike oral liquid in the treatment of mycoplasma pneumonia

作　　者：沈志峰[1] 阮学东[2] 

机构地区：[1]成都中医药大学附属医院儿科,成都610072 [2]绍兴市人民医院儿科,浙江绍兴312000

出　　处：《中国临床药理学杂志》2014年第7期563-564,574,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省绍兴市科技局基金资助项目(2003167)

摘　　要：目的回顾性分析阿奇霉素联合小儿消积止咳口服液治疗支原体肺炎(MP)的临床疗效及其对患儿体液免疫功能的影响。方法收治我科肺炎支原体感染患儿87例,其中单纯用阿奇霉素治疗者51例(对照组),用阿奇霉素联合小儿消积止咳口服液治疗者36例(试验组),比较2组患儿临床疗效及其体液免疫功能变化。结果治疗1周后,试验组临床有效率为88.9%,对照组为70.6%,试验组显著高于对照组(P<0.05)。2组患儿的血清免疫球蛋白M(IgM)、免疫球蛋白A(IgA)治疗后较治疗前均显著下降(P<0.05),但试验组下降更为显著(P<0.05)。试验组治疗48 h后咳嗽评分显著低于对照组(P<0.05)。结论阿奇霉素联合小儿消积止咳口服液可显著提高临床疗效,降低患儿体液免疫应答反应。Objective To evaluate the clinical efficacy of zithromax combined with Xiaoer Xiaoji Zhike oral liquid in the treatment of myco-plasma pneumonia and their effects on humoral immunity function.Methods Eighty-seven patients with mycoplasma pneumonia were in-cluded in this study.Of the 87 children , 51 were treated with zithromax （ control group ） and others were treated with zithromax combined with Xiaoer Xiaoji Zhike oral liquid （ experiment group ）.The clinical efficacy and serum immune index were compared between two groups after treat-ment.Results The clinical efficacy rate of experiment group （88.9%） was much higher than control group （ 70.6%） after one week treatment （ P〈0.05 ）.After treatment , the serum immunoglobulin M （ IgM ） and immunoglobulin A （ IgA） were significantly decreased in the two groups , with the experiment group decreasing more significantly （ P〈0.05 ）.The cough scores in the experiment group were significantly lower than that of the control group （ 〈0.05 ）.Conclusion Zithromax combined with Xiaoer Xiaoji Zhike oral liquid can significantly improve clinical efficacy and reduce the immune response in children .

关 键 词：支原体肺炎 阿奇霉素 体液免疫 小儿消积止咳口服液 

分 类 号：R978.15[医药卫生—药品]