左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床疗效  

Clinical effect of levonorgestrel- releasing intrauterine system in the treatment of endometriosis

作　　者：李晓红[1] 陈志芳[1] 丁岩[1] 

机构地区：[1]新疆医科大学第一附属医院妇科,乌鲁木齐830054

出　　处：《中国临床药理学杂志》2014年第7期571-574,共4页The Chinese Journal of Clinical Pharmacology

基　　金：新疆维吾尔自治区自然科学基金资助项目(2012211A066)

摘　　要：目的评价左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫内膜异位症(EM)的长期安全性。方法 49例EM患者用LNG-IUS治疗,于治疗前及治疗后6,12,36,60个月,比较患者的痤疮、面部色素沉着、乳房胀痛、体毛、生活质量评分和体重等变化。结果与治疗前相比,49例患者在随访各时间点,观察体毛评分、面部色素沉着评分与体重,差异均无统计学意义(均P>0.05);生活质量和乳房胀痛评分均显著好转,差异有统计学意义(均P<0.05)。与治疗前相比,痤疮评分在治疗6个月后差异无统计学意义(P>0.05),但治疗12,36,60个月后均明显降低(均P<0.05)。结论 LNG-IUS是一种可长期治疗EM的安全性较高的治疗方法。Objective To evaluate the safety of levonorgestrel -relea-sing intrauterine system （ LNG-IUS ） in the treatment of endometriosis （ EM） for 5 years.Methods A total of 49 patients with endometriosis were included.The LNG-IUS was inserted into uterine cavity.The ac-ne, facial pigmentation, mammary swelling, the body weight , the body hair and quality of life were scored and compared before and 6, 12, 36, and 60 months after the insertion of the LNG -IUS.Results Compared with prior treatment, the body weight and the scores of the body hair and facial pigmentation showed no marked change at each point of observation time （ P 〉0.05 ） , and the scores of quality of life and mammary swelling dropped significantly （ P〈0.05 ）.Six months after insertion, the score of acne had no marked change （ P〉0.05 ） , but 12, 36, and 60 months later, it decreased significantly （ P〈0.05 ）.Conclusion LNG -IUS is safe for long -term treat-ment of endometriosis.

关 键 词：左炔诺孕酮 药物缓释系统 子宫内膜异位症 安全性 

分 类 号：R711.7[医药卫生—妇产科学]