氟比洛芬酯对兔定量药物脑电图各频段功率百分比的影响  

Effects of flurbiprofen axetil on percentage of each band power of quantitative pharmaco- electroencephalography in rabbits

作　　者：徐佳雯[1] 于亚梅[1] 常永青[1] 李贺[1] 郭继龙[2] 戴体俊[3] 邵东华[4] 杭黎华[4] 

机构地区：[1] 徐州医学院 麻醉学院 [2] 徐州医学院附属医院 麻醉科 [3]徐州医学院麻醉学药理学教研室,江苏 徐州221002 [4]镇江市第一人民医院 麻醉科,江苏镇江212001

出　　处：《中国临床药理学杂志》2014年第7期615-616,共2页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30872432,30471657,39970715);江苏省社会发展科技计划基金资助项目(BS 200054);徐州医学院基金资助项目(2010YKYCX011)

摘　　要：目的观察氟比洛芬酯对家兔定量药物脑电图(QPEEG)各频段功率百分比的影响。方法 24只成年家兔随机分为4组:0.9%NaCl组和3个剂量(5,10,20 mg·kg-1)氟比洛芬酯组,用QPEEG和功率谱分析法,分析并观察兔耳缘静脉注射氟比洛芬酯前后脑电活动的变化。结果各剂量氟比洛芬酯组对家兔QPEEG各脑区、各频段的功率百分比均无明显影响(P>0.05)。结论氟比洛芬酯对家兔QPEEG各频段无明显影响,这与阿片类镇痛药有明显区别。Objective To investigate the effects of flurbiprofen axetil on percentage of each band power of quantitative pharmaco -electroence-hphalography （ QPEEG ） in rabbits.Methods Twenty -four healthy rabbits were randomly divided into four groups （ n =6 ）： 0.9%NaCl 1 mL· kg -1 group, flurbiprofen axetil 5, 10, and 20 mg · kg -1 groups.The QPEEG and power spectral analysis were adopted to analyze the changes of brain electrical activities before and after the intravenous in-jection of flurbiprofen axetil.Results Compared with the baseline , the percentages of each encephalic region and band power had no significant differences in these four groups （ P〉0.05 ）.Conclusion Flurbiprofen axetil has no obvious effect on percentage of each band power of quantita-tive pharmaco-electroencephalography in rabbits , suggesting that its site of action is not in the cerebral cortex.It is quite different from the opioid analgesics.

关 键 词：氟比洛芬酯 定量药物脑电图 作用机制 脑电活动 

分 类 号：R976[医药卫生—药品]