河北省各级精神卫生医疗机构抗精神药物使用频度的调查与分析  

Investigation and analysis on the frequency of anti- psychotropic drugs of all grades of mental health institutions in Hebei

作　　者：王健[1] 张云淑[1] 钱卫国[2] 翟京波[2] 孙秀丽[1] 严保平[1] 徐娜[1] 栗克清[1] 

机构地区：[1]河北省第六人民医院精神科,河北保定071000 [2]河北省卫生厅,石家庄050000

出　　处：《中国临床药理学杂志》2014年第7期632-634,641,共4页The Chinese Journal of Clinical Pharmacology

基　　金：2013年河北省医学科学研究重点课题计划基金资助项目(20130076)

摘　　要：目的调查河北省精神卫生机构2011年各类精神药物的使用情况。方法以河北省39家精神卫生机构2011年全年药品出库记录为对象,以限定日剂量(DDD)为指标,对精神药物使用情况进行统计分析。结果在三、二、一级医疗机构中,各种不同精神类药物排名居首位的如下:抗精神病药物分别是奎硫平(三级)、利培酮(二级)、氯氮平(一级);抗抑郁药分别是西酞普兰、帕罗西汀、阿米替林;情感稳定剂分别是丙戊酸镁缓释片、丙戊酸镁缓释片、丙戊酸钠。结论河北省各级医疗机构对精神药物使用情况当前均趋向于使用价格合理、疗效明确的新一代精神药物,但上述三级医疗机构比较存在明显差异。Objective To survey of the usage of psychotropic drugs in mental health institutions in Hebei province in 2011.Methods Use limit daily dose （ DDD） , pharmacoeconomics frequency analysis method and drug sales amount were as index.The drug outbound records of 39 mental health institutions in Hebei province on 2011 were analyzed.Re-sults The ranked first of psychotropic drugs in mental health institutions of different grades （ grade 3,2,1） were as followed.The ranked first of antipsychotic drug were quetiapine , risperidone, clozapinein in the 3,2, 1 institutions , respectively.The ranked first of antidepressants were cita-lopram, paroxetine, amitriptyline,in the 3,2,1 institutions, respectively.The ranked first of emotional stabilizer were magnesium valproate sus-tained-release tablets （ SR） , magnesium valproate SR , valproate in the 3,2,1 institutions, respectively.Conclusion Mental health institutions in Hebei province at all grades have tended to use the new generation of psychotropic drugs with reasonable -price, definite -curative, but significant differences exist in the medical institutions at differert levels.

关 键 词：限定日剂量 抗精神类药物 使用频度调查 用药分析 氯氮平 

分 类 号：R969.3[医药卫生—药理学]