18α-甘草酸固体脂质纳米粒抗大鼠急性肝损伤作用研究  

Protective Effect of 18α-Glycyrrhizic Acid Solid Lipid Nanoparticles on Acute Liver Injury in Rats

作　　者：王维[1] 潘旭旺 邵益丹 席建军 庄让笑 

机构地区：[1]浙江省人民医院,杭州310014 [2]杭州市西溪医院,杭州310023

出　　处：《中国现代应用药学》2014年第7期798-801,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：杭州市医药卫生科技计划项目(2008A019)

摘　　要：目的研究18α-甘草酸固体脂质纳米粒(18α-glycyrrhizic acid solid lipid nanoparticles,18α-GL-SLN)的抗大鼠急性肝损伤作用。方法用CCl4致大鼠急性肝损伤,以生化指标和病理变化评价18α-GL-SLN的抗肝损伤作用。结果与模型组比较,18α-GL-SLN各剂量组和18α-GL组ALT、AST、TBil、γ-GT、ALP水平明显降低,差异有统计学意义(P<0.05),提示对大鼠急性肝损伤均有一定的治疗作用,尤其是18α-GL-SLN中、高剂量组,效果优于18α-GL组(P<0.05);病理切片显示各给药组肝组织损伤明显减轻。结论 18α-GL-SLN有抗CCl4致大鼠急性肝损伤作用,并且其作用优于18α-GL。OBJECTIVE To investigate the protective effect of 18a-glycyrrhizic acid solid lipid nanoparticles （18a-GL-SLN） on acute liver injury in rats. METHODS Acute liver injury in rats was caused by CC14, and the protective effect of 18a-GL-SLN was evaluated with biochemical indicator and pathological change. RESULTS Compared with model group, different dosages groups of 18a-GL-SLN and 18a-GL group all obviously degraded the level of ALT, AST, TBil, ？-GT and ALP, it had statistical significance（P〈0.05）. This showed that the three groups of 18a-GL-SLN and the group of 18a-GL all had protective effect on acute liver injury in rats, and the effect of middle and high dose groups of 18a-GL-SLN were even better than group of 18a-GL（P〈0.05）. The pathological changes revealed that liver injury was relieved in all treated groups. CONCLUSION 18a-GL-SLN has the protective effect on acute liver injury in rats, and it resulted a better effect than 18a-GL.

关 键 词：18Α-甘草酸 固体脂质纳米粒 急性肝损伤 四氯化碳 

分 类 号：R965.2[医药卫生—药理学]