补肾通督胶囊对类风湿性关节炎患者TH1/TH2细胞平衡的影响  

Effect of Bushen Tongluo Capsule of Peripheral Th1/Th2 Ratio of Patients with Rheumatoid Arthritis

作　　者：朱阳春[1] 刘丹冰[2] 林琳[1] 侯丽萍[1] 

机构地区：[1]北京中医药大学,北京100029 [2]太原市类风湿病医院,山西太原030006

出　　处：《辽宁中医杂志》2014年第7期1451-1453,I0001,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：山西省科技攻关项目(20120313025-8)

摘　　要：目的:观察补肾通督胶囊对肾虚寒凝型类风湿性关节炎患者外周血Th1/Th2细胞及相关细胞因子干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)的影响。方法:入选类风湿性关节炎病例随机双盲分为治疗组(36例)和对照组(35例),治疗组口服补肾通督胶囊,对照组口服雷公藤多苷片,均服药12周,采用流式细胞术观察比较治疗前后两组患者外周血Th1/Th2及采用酶联免疫吸附法(ELISA)观察血清IFN-γ、IL-4、TNF-α、IL-1β的变化。结果:治疗后两组与各自组治疗前相比,Th1、Th1/Th2显著降低(P<0.01),Th2显著升高(P<0.01);治疗后两组间比较,治疗组Th2升高更为明显(P<0.01),对照组的Th1降低更为明显(P<0.01),Th1/Th2无显著性差异(P>0.05)。治疗后两组与各自治疗前相比,IFN-γ、TNF-α、IL-1β显著降低(P<0.01),IL-4显著升高(P<0.01);治疗后两组间比较,治疗组IL-4升高更为明显(P<0.01),对照组IFN-γ、TNF-α降低更为明显(P<0.01),IL-1β没有显著性差异(P>0.05)。结论:补肾通督胶囊可以明显改善肾虚寒凝型RA患者Th1/Th2的比例失衡。Objective：To investigate the effect of Bushen Tongluo capsule on peripheral Thl/Th2 ratio and serum IFN -γ, IL -4, TNF -α and IL- 1β of patients with rheumatoid arthritis （RA）. Methods：RA patients were divided randomly and double - blind into treatment group （36 cases） that was treated with Bushen Tongluo capsule and control group （35 cases） that was treated with Tripterygium glycosides tablet. Both groups were treated for 12 weeks. The changes of peripheral blood Thl/Th2 ratio and serum IFN -γ, IL - 4,TNF -α and IL - 1β were observed by flow cytometry and ELISA in two teams before and after the treatments. Results ：Ater treatments,peripheral Thl%, Thl/Th2 ratio significantly decreased and Th2% significantly evaluated（ P 〈 0. 01 ）in both groups. Compared with control group, peripheral Th2% evaluated more significanhy（ P 〈 0.01 ）. Thl % decreased less （ P 〈 0.01 ） and Th1/Th2 ratio was not statistically significant （ P 〉 0.05 ）. Serum IFN -γ, TNF -α , IL - 1β significantly decreased and IL -4 significantly evaluated （P 〈 0.01 ）. Compared with control group, IL -4 evaluated more （P 〈 0.01 ）. IFN -γ and TNF -α decreased less （ P 〈 0.01 ）. IL - 1β was not statistically significant （ P 〉 0.05 ）. Conclusion ： Bushen Tongluo capsule can improve the balance of Thl/Th2 cell of RA patients.

关 键 词：补肾通督胶囊 类风湿性关节炎 TH1 TH2 IFN-Γ IL-4 TNF-α IL-1β 

分 类 号：R593.22[医药卫生—内科学]