正交试验设计优选多聚甲醛的解聚方法  

Optimization of Depolymerization Method of Paraformldehyde by Orthogonal Experimental Design

作　　者：武晓琼[1] 闫荟[1] 杨锋[1] 贾阳[1] 

机构地区：[1]中国人民解放军北京军区总医院药剂科,北京100700

出　　处：《中国药业》2014年第14期62-64,共3页China Pharmaceuticals

摘　　要：目的优选多聚甲醛快速简单的解聚方法。方法采用正交试验法,以解聚状态为考察指标,对影响解聚的主要因素(温度、加热时间、振摇时间)进行优选。结果加热至95℃左右、120 min时多聚甲醛完全解聚,含量符合规定。结论该方法快速、简单,可直接用于稀甲醛的配制,适用于医院制剂室推广。Objective To optimize the fast and simple depolymerization method of paraformldehyde. Methods The orthogonal experiment method was adopted with the depolymerization status as the index, the main factors influencing the depolymerization： temperature,heating time and shaking time were optimized. Results Paraformldehyde was completely depolymerized at 95 ℃ for 120 min,the content accorded with the specification. Conclusion This method is quick and simple, can be directly used in the preparation of diluted formaldehyde and is suitable for the promotion in the preparation rooms.

关 键 词：多聚甲醛 正交试验 解聚 

分 类 号：R979.7[医药卫生—药品] R944.1[医药卫生—药学]