保心康对异丙肾上腺素致大鼠心肌缺血的保护作用  

Protection effects of Baoxinkang on myocardial injury induced by isoproterenol in rats

作　　者：朱芬芳[1] 李维祖[2] 张骏艳[2] 戴文杰[2] 朱瑞明[2] 尹艳艳[2] 

机构地区：[1]安徽大学,安徽合肥230601 [2]安徽医科大学,安徽合肥230032

出　　处：《安徽医药》2014年第8期1416-1419,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省大学生创新创业训练计划项目(No AH201310366005);安徽省高等学校优秀青年人才基金项目(No2012SQRL267)

摘　　要：目的观察保心康(BXK)对异丙肾上腺素(ISO)所致大鼠急性心肌缺血的保护作用。方法采用改良的Rona法复制大鼠急性心肌缺血模型,检测大鼠心电图(ECG)改变及血清中超氧化物歧化酶(SOD)活性、丙二醛(MDA)、乳酸(LD)、乳酸脱氢酶(LDH)以及肌酸磷酸激酶(CPK)含量,测定心肌含水量以及观察心肌组织病理改变。结果与心肌缺血模型组比较,BXK(18、36 mg·kg-1)可显著改善心肌缺血大鼠心电图S-T段抬高,明显提高心肌缺血大鼠血清中SOD活性,降低MDA含量,降低LD,LDH和CPK含量。BXK(18、36 mg·kg-1)能够不同程度减少心肌含水量及心肌缺血大鼠心肌组织病理损伤。结论保心康对大鼠急性心肌缺血模型具有明显的保护作用。Objective To observe the effect of Baoxinkang（BXK） on isoprenaline（ ISO）-induced acute myocardial ischemia（ AMI）.Methods Acute myocardial ischemia rats model was established by subcutaneous injection of ISO. Electro-cardiogram（ECG） was observed. Super oxide dismutase（SOD） activity,the contents of malondialdehyde（MDA） and lactic acid（LD）as well as lactate dehydrogenase（LDH） in the myocardial homogenate and creatine phosphokinase（CPK） were observed after ISO subcutaneous injection. Myocardial water contents were determined and pathological changes of myocardial tissue were observed. Results Compared with the model group,BXK（18、36 mg·kg^-1）could significantly improve the ECG S-T segment elevation of myocardial ischemia in rats,increase SOD activity,decrease contents of MDA and LD and LDH. It could also decrease contents of CPK. BXK（18、36 mg·kg^-1）could reduce myocardial water content and pathological changes of myocardial. The result has statistical significance. Conclusion BXK has therapeutic effect on ISO-induced myocardial ischemia injury.

关 键 词：保心康 心肌缺血 异丙肾上腺素 

分 类 号：R285.5[医药卫生—中药学]