^(131)碘治疗格雷夫斯病二次治疗的相关因素分析  

Related factors of second radioiodine therapy of Graves' disease

作　　者：程媛[1] 潘天荣[1] 杜益君[1] 钟兴[1] 王秀艳[1] 陶晓燕[1] 

机构地区：[1]安徽医科大学第二附属医院内分泌科,安徽合肥230601

出　　处：《安徽医药》2014年第8期1549-1552,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的部分格雷夫斯病患者进行1次131碘治疗后未能完全缓解,需要进行第2次131碘治疗,分析相关因素的影响。方法182例格雷夫斯病患者进行131碘治疗,治疗后随访6~12月。临床未治愈者进行第2次131碘治疗。所有患者根据是否进行第2次治疗分为:A组(一次性临床治愈组,148例)和B组(需要进行第2次治疗组,34例)。采集两组患者基本资料,检测血清甲状腺激素及相关抗体水平、进行核素功能检查。结果 A组和B组在性别、体重、甲状腺质量、甲状腺质量/体重的比值、甲状腺摄锝率、第1次131碘治疗剂量方面的差异有统计学意义(P<0.05),其余指标两组间差异均无统计学意义(P>0.05)。Logistic回归分析显示,甲状腺质量/体重的比值、甲状腺摄锝率是格雷夫斯病患者在1次131碘治疗后需要进行第2次131碘治疗的独立相关因素。结论临床医生应用131碘治疗格雷夫斯病患者时,综合考虑多个相关因素确定治疗剂量,将有助于一次性临床治愈疾病。Objective To analyze the impact of related factors among the patients of Graves＇ disease who failed to complete remission after radioiodine therapy and needed second treatment. Methods A hundred and eighty-two patients with Graves＇ disease were followed up for 6 to 12 months after radioiodine therapy. Those who were not cured were treated by second radioiodine therapy. All of the patients were assigned into two groups：group A（the one-time cured patients,148 cases） and group B（the patients who needed a second therapy,34 cases）. The basic data of all the patients were collected and serum thyroid hormones,related antibody level,nuclide function of thyroid gland were detected. Results The differences between group A and group B in sex,weight,thyroid mass,the ratio of thyroid mass to body weight,thyroid gland＇s intake rate of technetium,the dose of radioiodine in the first therapy were statistically significant. The other indicators had no significant differences between the two groups. Conclusions Considering multiple factors to determine therapeutic dose of the radioiodine therapy on Graves＇ disease will help the clinical cure of the disease.

关 键 词：格雷夫斯病 ^131碘治疗 

分 类 号：R581.1[医药卫生—内分泌]