乐卡地平与培哚普利联合治疗轻中度高血压疗效及安全性观察  

Efficacy and safety of perindopril combined with lercanidipine in the treatment of mild essential hypertensive patients

作　　者：吴丁烨[1] 张煜[1] 顾向红[1] 羊镇宇[1] 

机构地区：[1]南京医科大学附属无锡人民医院心血管内科,江苏无锡214023

出　　处：《安徽医药》2014年第8期1559-1561,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的评价乐卡地平与培哚普利小剂量单独治疗和联合治疗轻度原发性高血压的疗效及安全性。方法 180例轻度原发性高血压患者随机分成联合治疗组(A组)和单用乐卡地平组(B组)和单用培哚普利组(C组)。A组服用培哚普利2 mg·d-1+乐卡地平5 mg·d-1;B组服用乐卡地平10 mg·d-1;C组服用培哚普利4 mg·d-1。分别观察三组治疗后4、8、12周后降压效果及安全性。结果联合治疗组第4周开始,血压达标率及血压下降幅度均优于单药治疗组,三组间差异有统计学意义(P<0.05)。联合治疗组治疗期间不良事件发生4例,明显低于单药治疗组(乐卡地平组7例,培哚普利组19例),差异有显著性(P<0.05)。结论乐卡地平与培哚普利联合应用可明显增加降压幅度和降压速度、提高降压有效率,两药小剂量联合可减少药物不良反应发生率。Objective To investigate the efficacy and safety of combination of perindopril and lercanidipine comparing with perindopril or lercanidipine only for mild essential hypertensive patients. Methods A hundred and eighty patients with mild essential hypertension were randomized into three groups：group A（perindopril 2 mg·d^-1plus lercanidipine 5 mg·d^-1）,group B（lercanidipine 10 mg·d^-1） and group C（perindopril 4 mg·d^-1）. The efficacy of treatment and adverse effects were evaluated at the end of 4,8 and 12weeks after treatment. Results The blood pressure in group A was lower than that in group B and group C at the end of 4 weeks after treatment. Compared with group B and group C,the reaching target blood pressure rate was better in group A. Differences had statistical meaning at the end of 8 weeks among three groups（P〈0. 05）. There were 4 cases of ADR in group A,which is significantly lower than that in group B（7 cases） and in group C（19 cases）. There were significant differences in adverse reaction among three groups. Conclusions Low-dose combination of lercanidipine and perindopril is effective and safe in the treatment of mild hypertension.

关 键 词：乐卡地平 培哚普利 联合治疗 高血压 疗效 

分 类 号：R544.1[医药卫生—心血管疾病]