原发性高血压患者静息心率与颈动脉粥样硬化的关系  

Relationship between resting heart rate and carotid atherosclerosis in essential hypertension

作　　者：黄雨晴[1] 魏学标[2] 詹嘉欣[1] 周颖玲[1] 陈纪言[1] 蒋磊[2] 张莹[1] 冯颖青[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)广东省心血管病研究所心内科,在读研究生广州510000 [2]南方医科大学广东省人民医院(广东省医学科学院)心内科

出　　处：《中华临床医师杂志（电子版）》2014年第13期1-4,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：广东省科技计划(2010B031500019;2011B03180007)

摘　　要：目的：探讨新发现的原发性高血压患者静息心率（RHR）与颈动脉粥样硬化（CAS）的关系及分析RHR对CAS发生的预测价值。方法从广东省人民医院参与的阜外医院牵头的公益性行业科研项目：“心血管病危险因素监测及高血压规范化管理”高血压数据库中随机选取新发现的原发性高血压患者，按RHR水平分为3组：RHR＜70次/min为A组、70-80次/min为B组、≥80次/min为C组，比较各组间资料的差异，分析不同RHR间CAS的发生率，并绘制工作特征曲线（ROC）分析RHR对CAS预测价值。结果共有260例患者纳入本研究，男118例，女142例，平均年龄（62.3±11.0）岁，其中A组125例（48.1%）、B组81例（31.2%）、C组54例（20.7%）；各组间年龄、血压、空腹血糖、血脂、BMI均无统计学意义（均P＞0.05），CAS发生率三组间逐渐升高（分别为16.0%、33.3%、62.9%；P＜0.05），RHR与CAS间的ROC曲线显示：曲线下面积（AUC）＝0.769（P＜0.05），特异度为53.1%，灵敏度为87.7%。结论在新发现的原发性高血压患者中，CAS发生率随着RHR增加而升高，RHR对CAS的发生率有一定的预测价值。ObjectiveTo investigate the relationship between resting heart rate（RHR） and carotid atherosclerosis （CAS） and analysis the predictive value of CAS in essential hypertension diagnosed newly.MethodsAll participants were from the hypertension database, namely, was organized by Fuwai hospital, that Guangdong General Hospital participated in public welfare industry scientific research project： “To monitor cardiovascular disease risk factors and hypertension standardized management”. All participatants were divided into three groups depending on the levels of resting heart rate： A group, RHR〈70 beats/min, B group, 70 beats/min≤RHR〈80 beats/min, C group, RHR≥80 beats/min. The difference of basic information （such as age, sex, etc） were compared, and the incidence of CAS among groups were analyzed. Characteristic curve （ROC） was used to analysis the predictive value of RHR to CAS. Results A total of 260 participatants were enrolled in this study [male 118, female 142, age （62.3±11.0） years], with 125 subjects in group A （48.1%）, 81 （31.2%） subjects in group B, 54（20.7%） subjects in group C. Among groups age, blood pressure, fasting blood glucose, blood lipid, body mass index were all had no statistical significance（allP〉0.05）. But the incidence of CAS among the three groups increased significantly （16.0%, 33.3%, 62.9%,P〈0.05）. The ROC curve of the relationship between RHR and CAS demonstrated that the largest area under the curve （AUC） was 0.769（P〈0.05）, specificity and sensitivity was 53.1% and 87.7%, respectively.Conclusion In essential hypertension diagnosed newly, the incidence of CAS increased by RHR, and RHR was valuable to predict CAS.

关 键 词：高血压 心率 动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]