微重力对骨髓间充质干细胞成骨分化的影响  

Effects of microgravity on bone marrow mesenchymal stem cells into osteogenic differentiation

作　　者：张新昌[1,2] 韩标[1] 王强松[1] 李昊[1] 张西正[1] 

机构地区：[1]军事医学科学院卫生装备研究所,天津300161 [2]武警后勤学院生物化学与分子生物学教研室,天津300162

出　　处：《国际生物医学工程杂志》2014年第3期175-178,共4页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（31370942）

摘　　要：骨髓间充质干细胞（BMSCs）是一种多能成体于细胞,是组织工程重要的种子细胞来源之一.微重力对BMSCs成骨分化具有抑制作用,可使骨量减少和骨微结构改变,从而导致骨质疏松症.这一过程受到多条信号通路的调控,如MAPK信号通路、Notch信号通路和Wnt/β-catenin信号通路等,它们协同调节微重力下BMSCs向成骨细胞方向的分化.研究微重力对BMSCs成骨分化的影响,可以阐明骨质流失机理,为相关疾病的治疗提供新的靶点,促进我国太空宇航事业的发展.Bone marrow mesenchymal stem cells （BMSCs） is a kind of multipotent adult stem cells,which is one of the most important seed sources of tissue engineering.Microgravity has inhibitory effects on osteogenic differentiation of BMSCs,which will cause bone mass reduction and changes of bone micro-structure that finally lead to osteoporosis.This process is regulated by multiple signaling pathways such as mitogen-activated protein kinase （MAPK） pathway,Notch pathway and Wnt/β-catenin pathway which co-regulated BMSCs osteogenic differentiation under microgravity.Studying the effects of microgravity on BMSCs into osteogenic differentiation can clarify the mechanism of bone loss,put forward new targets for the treatment of diseases and provide a useful reference for the development of China＇s space industry.

关 键 词：微重力 骨髓间充质干细胞 成骨分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]