基因组学技术在机械通气相关性肺损伤基因活化中的应用  

Application of genome-wide measurements in gene activation of ventilator-induced lung injury

作　　者：钟琦[1] 张宗泽[1] 陈畅[1] 

机构地区：[1]武汉大学附属中南医院麻醉科,430071

出　　处：《国际呼吸杂志》2014年第14期1099-1106,共8页International Journal of Respiration

基　　金：国家自然科学基金（81000318）;武汉青年科技晨光计划项目（201271031425）

摘　　要：机械通气是临床广泛应用的通气方式，它大大增加了重危患者抢救的成功率。然而，不合理的应用也可能产生和加重原有肺损伤，引起机械通气相关性肺损伤（VILI）。目前，VILI的基因表达及基因产物研究取得了很大进展，如早期诱导基因活化、临床敏感基因定位、基因信号传导通路等。而探讨基因组学技术在VILI中病理生理机制的应用，丰富和完善VILI理论，并为VILI提供有效的药物治疗方法。通过识别VILI中的相关因素，我们可利用其对VILI的危险人群进行识别。随着VILI的学科机制的完善与发展，关于VILI发病机制的完整性描述将会成为可能。Mechanical ventilation （MV） is a ubiquitous mode in clinical care,which is a life-saving intervention in critical patients. But clinical trials have demonstrated that unreasonable MV plays a role inpromoting and perpetuating lung injury and leads to ventilator-induced lung injury （VILI）. At present, the researches of the gene expression and the gene products in VILI have made considerable advances, forexample,gene activation early induced, location of sensitivity gene, and gene signaling pathways. The application of genome-wide measurements in the pathophysiology of VILI provides effective drug therapyfor improving VILI. Through the recognition of the relevant factors in VILI, we can identify the risk population. With the development of researches on VILI, a complete picture of the pathogenesis may be possible.

关 键 词：基因表达 机械通气 信号通路 机械相关性肺损伤 

分 类 号：R563.8[医药卫生—呼吸系统]